Liquid based cytology method investigation of definite cytology diagnosis on salivary gland carcinoma and analysis of prognostic factor
| Project/Area Number |
25871069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
Surgical dentistry
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Sato Yukiko 公益財団法人がん研究会, 有明病院 病理部, 医員 (30365712)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | LBC / FISH / 唾液腺腫瘍 / MYB / NFIB / MYBL1 / 融合遺伝子 / EWSR1 / 細胞診 / 悪性度 / 唾液腺 |
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| Outline of Final Research Achievements |
The pupose of this study is to bring treatment option and improve prognosis by definitive cytologic diagnosis on histologic subtype in salivary gland tumor(SGT). SGT treatment has recently changing strategy by histologic subtype. SGT which has large number of parotid gland onset, is difficult to establish tissue type on preoperative diagnosis which generally uses fine needle aspiration cytology.
Adenoid cystic carcinoma, which has analogue of histologic type and negative on nuclear atypia, was effective on examination of FISH method, MYB, MYBl1 and NFB1. FISH was generally conducted by formalin fixed paraffin embedded tissue.
we have examined the feasibility of cytology to detect specific fusion gene by each histologic type and announced results on conference presentation. We found cytologic diagnosis extremely valuable on FISH method of adenoid cyctic carcinoma which brings less burden on biopsy and more accuracy on treatment strategy.
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan.2017
Author(s)
Kawakita D, Tada Y, Imanishi Y, Beppu S, Tsukahara K, Kano S, Ozawa H, Okami K, Sato Y, Shimizu A, Sato Y, Fushimi C, Takase S, Okada T, Sato H, Otsuka K, Watanabe Y, Sakai A, Ebisumoto K, Togashi T, Ueki Y, Ota H, Shimura T, Hanazawa T, Murakami S, Nagao T.
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Journal Title
Oncotarget
Volume: 8(1)
Issue: 1
Pages: 1083-1091
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene.2017
Author(s)
Kujiraoka S, Tsunematsu T, Sato Y, Yoshida M, Tohyama R, Tanaka M, Kobayashi Y, Kondo T, Ushio A, Otsuka K, Kurosawa M, Saito M. Yamada A, Arakaki R, Nagai H, Nikai H, Takeuchi K, Nagao T, Miyamoto Y, Ishimaru N, Kudo Y.
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Journal Title
Oral Oncol.
Volume: 69
Pages: 46-55
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical Outcomes and Prognostic Factors for Salivary Duct Carcinoma: A Multi-Institutional Analysis of 141 Patients2016
Author(s)
Otsuka K, Imanishi Y, Tada Y, Kawakita D, Kano S, Tsukahara K, Shimizu A, Ozawa H, Okami K, Sakai A, Sato Y, Ueki Y, Sato Y, Hanazawa T, Chazono H, Ogawa K, Nagao T.Ann Surg Oncol.
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Journal Title
Ann Surg Oncol.
Volume: 23
Issue: 6
Pages: 2038-2045
DOI
Related Report
Peer Reviewed / Open Access
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