Identification of novel tyrosine kinase fusion genes in colorectal cancer

• Project/Area Number: 25871072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology; Experimental pathology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: SAKATA Seiji 公益財団法人がん研究会, 分子標的病理プロジェクト, 研究員 (00617433)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: チロシンキナーゼ / 融合遺伝子

Outline of Final Research Achievements

We found several novel tyrosine kinase fusion genes in colorectal cancer using a histopathology-based screening system. We analyzed clinicopathological data and other gene mutations in colorectal cancers with the identified fusion genes. We are investigating tumorigenicity and drug sensitivity of the identified fusion genes.

Research Products

• [Journal Article] 上皮性腫瘍における融合遺伝子 (2014)
  • Author(s): 竹内賢吾、坂田征士（共同執筆）
  • Journal Title: 実験医学 Volume: 32 Pages: 1948-1954
• [Patent(Industrial Property Rights)] XX融合体の検出法 (2014)
  • Inventor(s): 竹内賢吾、冨樫由紀、坂田征士、馬場響子
  • Industrial Property Rights Holder: がん研究会
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-07-25
  • Overseas
• [Patent(Industrial Property Rights)] 新規融合体及びその検出法(YY) (2014)
  • Inventor(s): 竹内賢吾、冨樫由紀、坂田征士、藤田直也、片山量平
  • Industrial Property Rights Holder: がん研究会
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-10-29
  • Overseas
• [Patent(Industrial Property Rights)] 新規融合体及びその検出法(ZZ) (2014)
  • Inventor(s): 竹内賢吾、朝賀礼美、坂田征士、藤田直也、片山量平
  • Industrial Property Rights Holder: がん研究会
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-10-29
  • Overseas