The molecular mechanisms and regulation of acquisition of tumor invasive abilities through actin cytoskeleton remodeling
| Project/Area Number |
25871074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
Tumor therapeutics
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| Research Institution | Microbial Chemistry Research Foundation (2015)
Tokyo Metropolitan Institute of Medical Science (2014)
Japanese Foundation for Cancer Research (2013) |
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Principal Investigator |
OHISHI Tomokazu 公益財団法人微生物化学研究会, 沼津支所, 研究員 (50442546)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アクチン細胞骨格 / 細胞運動 / 浸潤 / ポリ(ADP-リボシル)化 / ポリADP-リボースポリメラーゼ |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the function of TAB182, which is a binding protein of poly(ADP-ribose)polymerase tankyrase, and the involvement of TAB182 dysfunction in the regulation of cancer cells migration and invasion. 1) TAB182 depletion activated the ROCK-LIMK pathway, which is overexpressed in various cancer cells, and enhanced cancer cell migration and invasion. Tankyrase overexpression also activated the ROCK-LIMK pathway without depletion of TAB182. 2) To investigate the involvement of TAB182 expression changes in the clinical cancer setting, we performed tissue microarray-based immunohistochemistry. Among various cancers, TAB182 expression was significantly lower in the area of invasion than that of non-invasion in pancreatic cancer.
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Report
(4 results)
Research Products
(10 results)
