Regulation of myoblast differentiation through the endoplasmic reticulum (ER) membrane dynamics caused by ER stress
| Project/Area Number |
25871124
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cell biology
General anatomy (including histology/embryology)
|
|---|
| Research Institution | Nara Institute of Science and Technology (2016)
Institute of Physical and Chemical Research (2013-2015) |
|---|
Principal Investigator |
Nakanishi Keiko 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (30415252)
|
|---|
| Research Collaborator |
MORISHIMA NOBUHIRO 国立研究開発法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 (40182232)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 細胞分化 / 小胞体ストレス / オルガネラ動態 / 筋芽細胞 / カルシウム / STIM1 / 筋発生 / 小胞体膜動態 |
|---|
| Outline of Final Research Achievements |
We previously reported that endoplasmic reticulum (ER) stress signaling caused physiologically during myoblast differentiation plays important roles for the differentiation. However, the mechanism which causes the ER stress signaling was unknown. We investigated correlation between ER membrane dynamics and alterations in ER homeostasis, and revealed that ER calcium depletion is the cause of ER stress during myotube formation.
|
Report
(5 results)
Research Products
(8 results)
