| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The purpose of the present research project is to construct multi-scale mathematical models representing disease progression. A particular focus of this study is to describe the progression of atopic dermatitis as a representative skin inflammatory disease. One of mathematical analyses conducted in this research project includes propagation of the inflammatory response at the epidermis tissue. Moreover, interactions amount protease activity and immune response was incorporated to investigate how chronic inflammation is maintained. The later of the project has been in preparation to submit a peer review journal. This work is done by an international collaboration. In addition, study on determining an appropriate numerical computation scheme was examined to develop an efficient and useful computation scheme to implement numerical simulations for multi-scale models. These achievements will be further improved to obtain clear understanding on multi-scale dynamics in disease progression.
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