| Project/Area Number |
25871153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Sakoda Hideyuki 国立医薬品食品衛生研究所, 医療機器部, 主任研究官 (50443099)
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| Research Collaborator |
SUGANO Nobuhiko 大阪大学, 医学系研究科・寄付講座, 教授 (70273620)
KAWAKAMI Tsuyoshi 国立医薬品食品衛生研究所, 生活衛生化学部, 主任研究官 (00434043)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 人工関節 / 超高分子量ポリエチレン / 生体脂質 / 耐久性 |
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| Outline of Final Research Achievements |
Lipids such as squalene （SQ） have been reported to be absorbed in ultra-high molecular weight polyethylene （UHMWPE） components of joint prostheses during use in vivo. SQ absorption and subsequent accelerated aging was found to induce the degradation of the mechanical and wear properties of UHMWPE in vitro, especially near the surfaces. Investigation of retrieved components revealed the degraded strength near the surfaces in most of the components, indicating lipid-induced degradation of UHMWPE in vivo. Larger quantities of extracts were collected from components retrieved from patients with osteoarthritis than those from patients with fracture or osteonecrosis, indicating the influence of the differences in constituents of the joint fluids due to the disease.
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