Analysis of NPM mutant-mediated acute myeloid leukemia
Project/Area Number |
25871159
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
Tumor biology
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Research Institution | National Cancer Center Japan |
Principal Investigator |
OGAWARA Yoko 独立行政法人国立がん研究センター, 研究所, 研究員 (30599626)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | NPM / IDH / AML / 2HG / 5hmC / 低酸素 / YB-1 |
Outline of Final Research Achievements |
In normal karyotype acute myeloid leukemia (AML), simultaneous mutations in NPM, IDH, DNMT3A and FLT3 occur frequently. We generated AML mouse model, the onset of which depends on these four mutant genes. By using these AML model mice, we showed that IDH mutant inhibits differentiation of cells and is necessary for the maintenance of leukemia stem cells. This study is the first to demonstrate that IDH mutant is a reasonable therapeutic target for cancer.
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Report
(3 results)
Research Products
(15 results)
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[Presentation] 変異型IDHの急性骨髄性白血病における機能2014
Author(s)
Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
Organizer
第87回日本生化学会
Place of Presentation
国立京都国際会館
Year and Date
2014-10-15 – 2014-10-18
Related Report
Invited
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[Presentation] IDH mutant and cancer2014
Author(s)
Yoko Ogawara, Takuo Katsumoto, Yutaka Shima, Tomoyoshi Soga, Issay Kitabayashi
Organizer
第73回日本癌学会学術集会
Place of Presentation
パシフィコ横浜
Year and Date
2014-09-25 – 2014-09-27
Related Report
Invited
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[Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2014
Author(s)
Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
Organizer
2014 Keystone Symposia Conference, X6: Tumor Metabolism
Place of Presentation
Whistler, Canaa
Related Report
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