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Analysis of NPM mutant-mediated acute myeloid leukemia

Research Project

Project/Area Number 25871159
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Tumor biology
Research InstitutionNational Cancer Center Japan

Principal Investigator

OGAWARA Yoko  独立行政法人国立がん研究センター, 研究所, 研究員 (30599626)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsNPM / IDH / AML / 2HG / 5hmC / 低酸素 / YB-1
Outline of Final Research Achievements

In normal karyotype acute myeloid leukemia (AML), simultaneous mutations in NPM, IDH, DNMT3A and FLT3 occur frequently. We generated AML mouse model, the onset of which depends on these four mutant genes. By using these AML model mice, we showed that IDH mutant inhibits differentiation of cells and is necessary for the maintenance of leukemia stem cells. This study is the first to demonstrate that IDH mutant is a reasonable therapeutic target for cancer.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (15 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Invited: 4 results)

  • [Journal Article] IDH2 and NPM1 Mutations Cooperate to Activate Hoxa9/Meis1 and Hypoxia Pathways in Acute Myeloid Leukemia2015

    • Author(s)
      Ogawara Y, Katsumoto T, Aikawa Y, Shima Y, Kagiyama Y, Soga T, Matsunaga H, Seki T, Araki K, Kitabayashi I.
    • Journal Title

      Cancer Res.

      Volume: 75 Issue: 10 Pages: 2005-2016

    • DOI

      10.1158/0008-5472.can-14-2200

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] AMLにおけるエピゲノム変化 IDH標的研究2014

    • Author(s)
      小川原陽子、 北林一生
    • Journal Title

      実験医学

      Volume: 37 Pages: 1977-1981

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 変異型IDHを標的とした治療法開発の現状と展望2014

    • Author(s)
      小川原陽子、 北林一生
    • Journal Title

      細胞

      Volume: Vol. 46 No. 3 Pages: 20-24

    • Related Report
      2013 Research-status Report
  • [Journal Article] IDH 変異を標的とした新たながん治療戦略2014

    • Author(s)
      小川原陽子、 北林一生
    • Journal Title

      細胞工学

      Volume: Vol. 33 No. 2 Pages: 145-150

    • Related Report
      2013 Research-status Report
  • [Presentation] 変異型IDHの急性骨髄性白血病における機能2015

    • Author(s)
      小川原 陽子、町田 雪乃、北林 一生
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08 – 2015-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IDH mutants are promising therapeutic targets for acute myeloid leukemia2015

    • Author(s)
      Yoko Ogawara, Hironori Matsunaga, Takahiko Seki, Yukino Machida, Kazushi Araki, Issay Kitabayashi
    • Organizer
      AACR Annual Meeting 2015
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] IDH変異体の急性骨髄性白血病における機能2015

    • Author(s)
      小川原 陽子、 北林 一生
    • Organizer
      第19回造血器腫瘍研究会
    • Place of Presentation
      佐賀
    • Year and Date
      2015-01-23 – 2015-01-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] IDH mutant regulates metabolism and hypoxia pathway in AML2014

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
    • Organizer
      第76回血液学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 変異型IDHの急性骨髄性白血病における機能2014

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IDH mutant and cancer2014

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto, Yutaka Shima, Tomoyoshi Soga, Issay Kitabayashi
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2014

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Tomoyoshi Soga, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
    • Organizer
      第12回幹細胞シンポジウム
    • Place of Presentation
      九州大学医学部
    • Year and Date
      2014-05-30 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2014

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Hironori Matsunaga, Takahiko Seki, Kazushi Araki, Issay Kitabayashi
    • Organizer
      2014 Keystone Symposia Conference, X6: Tumor Metabolism
    • Place of Presentation
      Whistler, Canaa
    • Related Report
      2013 Research-status Report
  • [Presentation] Critical roles of the IDH2 mutation in development and maintenance of acute myeloid leukemia2013

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto, Yukiko Aikawa, Yutaka Shima, Yuki Kagiyama, Hironori Matsunaga, Takahiko Seki and Issay Kitabayashi
    • Organizer
      55th American Society of Hematology, Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] NPMc cooperates with IDH2 mutant to induce AML2013

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto and Issay Kitabayashi
    • Organizer
      第75回日本血液学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] NPMc cooperates with IDH2 mutant to induce AML」English oral presentation.2013

    • Author(s)
      Yoko Ogawara, Takuo Katsumoto and Issay Kitabayashi
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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