Function of IELs in the development of IBD.

• Project/Area Number: 25871164
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology; Digestive surgery
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: ODA Hiroyo 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 (10450595)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 非典型T細胞 / 胸腺特異的遺伝子 / 自己免疫 / T細胞特異的遺伝子 / 腸炎 / プロテオミクス / T細胞 / IEL / 胸腺特異的遺伝子群 / 分化 / 誘導型腸炎

Outline of Final Research Achievements

Dysregulation of immune response plays important roles in the pathogenesis of IBD.
To understand the role of T cells in IBD, we focused on the function of T cell specific genes (ISC1~13) in the development and function of T cells.
We newly identified 4 candidate proteins that can associate with ISC4 in T cells.

Research Products

• [Journal Article] Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. (2015)
  • Author(s): Tamehiro N, Oda H, Shirai M, Suzuki H.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0131047-e0131047
  • DOI: 10.1371/journal.pone.0131047
  • Peer Reviewed / Open Access
• [Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells. (2015)
  • Author(s): Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
  • Journal Title: EMBO Rep. Volume: なし Issue: 5 Pages: 638-653
  • DOI: 10.15252/embr.201540096
  • Peer Reviewed
• [Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells. (2015)
  • Author(s): Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y,T Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H.
  • Journal Title: EMBO Rep Volume: 16 Pages: 638-53
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Differential Function of Themis CABIT Domains during T Cell Development. (2014)
  • Author(s): Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e89115-e89115
  • DOI: 10.1371/journal.pone.0089115
  • Peer Reviewed
• [Journal Article] MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. (2013)
  • Author(s): Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C.
  • Journal Title: EMBO J Volume: 32 Issue: 17 Pages: 2377-2391
  • DOI: 10.1038/emboj.2013.178
  • Peer Reviewed
• [Presentation] RhoH is essential for development of IL-17- producing γδ T cell (2015)
  • Author(s): Muro Ryunosuke, NITTA Takeshi, TAMEHIRO Norimasa, ODA Hiroyo , SUZUKI Harumi
  • Organizer: 第４４回日本免疫学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2015-11-19
• [Presentation] Role of RhoH in differentiation and function of various types of T cells (2015)
  • Author(s): SUZUKI Harumi, TAMEHIRO Norimasa, MURO Ryunosuke, ODA Hiroyo, NITTA Takeshi
  • Organizer: 第４４回日本免疫学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2015-11-18
• [Presentation] ISC13 is essential for IL-2 production in T cells. (2014)
  • Author(s): ODA Hiroyo, KITAJIMA Masayuki, OKADA Toshiyuki, SUZUKI Harumi
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Over-expression of RhoH activetes the transition of CD4-CD8- (DN) to CD4+CD8+ (DP) cells in RAG-/- background. (2014)
  • Author(s): TAMEHIRO Norimasa, ODA Hiroyo, SUZUKI Harumi
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Themis is important for differentiation of regulatory T cells (2014)
  • Author(s): OKADA Toshiyuki, NITTA Takeshi, KITAJIMA Masayuki, ODA Hiroyo, SUZUKI Harumi
  • Organizer: The 43rd Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: 京都
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Themis regulates cytokine production in mature naive T cells (2014)
  • Author(s): Toshiyuki Okada, Takeshi Nitta, Hiroyo Oda, Norimasa Tamehiro, Michael S Patrick and Harumi Suzuki
  • Organizer: ThymOz
  • Place of Presentation: オーストラリア ヘロン島
  • Year and Date: 2014-04-02 – 2014-04-06
• [Presentation] RhoH 欠損マウスで認められる乾癬様皮膚炎の解析 (2014)
  • Author(s): 爲廣紀正、小田浩代、鈴木春巳
  • Organizer: Kyoto T Cell Conference(KTCC) 第24回学術集会
  • Place of Presentation: 京都
• [Presentation] 胸腺皮質上皮細胞によるγδT 細胞の分化制御 (2014)
  • Author(s): 新田 剛、室 龍之介、新田 幸子、小田 浩代、鈴木 春巳
  • Organizer: Kyoto T Cell Conference(KTCC) 第24回学術集会
  • Place of Presentation: 京都
• [Presentation] Differential function of two CABIT domains in Themis (2013)
  • Author(s): Toshiyuki Okada, Takeshi Nitta, Hiroyo Oda, Michael S patrick and Harumi Suzuki
  • Organizer: 第４２回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] Cortical thymic epithelial cells control conventional and innate T cell development (2013)
  • Author(s): Takeshi Nitta, Ryunosuke Muro, Hiroyo Oda,Shigeo Murata, Harumi Suzuki
  • Organizer: 第４２回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Invited
• [Presentation] A non-synonymous SNP variant of RhoH reduces TCR mediated signal transducion via proteasomal degradation (2013)
  • Author(s): Norimasa Tamehiro, Hiroyo Oda, Harumi Suzuki
  • Organizer: 第４２回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] Themis CABIT domains exert distinct functions in thymocyte positive selection (2013)
  • Author(s): Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Hiroyo Oda, Michael S Patrick and Harumi Suzuki
  • Organizer: 15th ICI(International Congress of Immunology)
  • Place of Presentation: Milan, Italy