• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Function of IELs in the development of IBD.

Research Project

Project/Area Number 25871164
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Digestive surgery
Research InstitutionNational Center for Global Health and Medicine

Principal Investigator

ODA Hiroyo  国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 (10450595)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords非典型T細胞 / 胸腺特異的遺伝子 / 自己免疫 / T細胞特異的遺伝子 / 腸炎 / プロテオミクス / T細胞 / IEL / 胸腺特異的遺伝子群 / 分化 / 誘導型腸炎
Outline of Final Research Achievements

Dysregulation of immune response plays important roles in the pathogenesis of IBD.
To understand the role of T cells in IBD, we focused on the function of T cell specific genes (ISC1~13) in the development and function of T cells.
We newly identified 4 candidate proteins that can associate with ISC4 in T cells.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Invited: 1 results)

  • [Journal Article] Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.2015

    • Author(s)
      Tamehiro N, Oda H, Shirai M, Suzuki H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0131047-e0131047

    • DOI

      10.1371/journal.pone.0131047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells.2015

    • Author(s)
      Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
    • Journal Title

      EMBO Rep.

      Volume: なし Issue: 5 Pages: 638-653

    • DOI

      10.15252/embr.201540096

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.2015

    • Author(s)
      Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y,T Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H.
    • Journal Title

      EMBO Rep

      Volume: 16 Pages: 638-53

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential Function of Themis CABIT Domains during T Cell Development.2014

    • Author(s)
      Okada T, Nitta T, Kaji K, Takashima A, Oda H, Tamehiro N, Goto M, Okamura T, Patrick MS, Suzuki H.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e89115-e89115

    • DOI

      10.1371/journal.pone.0089115

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.2013

    • Author(s)
      Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C.
    • Journal Title

      EMBO J

      Volume: 32 Issue: 17 Pages: 2377-2391

    • DOI

      10.1038/emboj.2013.178

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] RhoH is essential for development of IL-17- producing γδ T cell2015

    • Author(s)
      Muro Ryunosuke, NITTA Takeshi, TAMEHIRO Norimasa, ODA Hiroyo , SUZUKI Harumi
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of RhoH in differentiation and function of various types of T cells2015

    • Author(s)
      SUZUKI Harumi, TAMEHIRO Norimasa, MURO Ryunosuke, ODA Hiroyo, NITTA Takeshi
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ISC13 is essential for IL-2 production in T cells.2014

    • Author(s)
      ODA Hiroyo, KITAJIMA Masayuki, OKADA Toshiyuki, SUZUKI Harumi
    • Organizer
      The 43rd Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Over-expression of RhoH activetes the transition of CD4-CD8- (DN) to CD4+CD8+ (DP) cells in RAG-/- background.2014

    • Author(s)
      TAMEHIRO Norimasa, ODA Hiroyo, SUZUKI Harumi
    • Organizer
      The 43rd Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Themis is important for differentiation of regulatory T cells2014

    • Author(s)
      OKADA Toshiyuki, NITTA Takeshi, KITAJIMA Masayuki, ODA Hiroyo, SUZUKI Harumi
    • Organizer
      The 43rd Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Themis regulates cytokine production in mature naive T cells2014

    • Author(s)
      Toshiyuki Okada, Takeshi Nitta, Hiroyo Oda, Norimasa Tamehiro, Michael S Patrick and Harumi Suzuki
    • Organizer
      ThymOz
    • Place of Presentation
      オーストラリア ヘロン島
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Research-status Report
  • [Presentation] RhoH 欠損マウスで認められる乾癬様皮膚炎の解析2014

    • Author(s)
      爲廣紀正、小田浩代、鈴木春巳
    • Organizer
      Kyoto T Cell Conference(KTCC) 第24回学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 胸腺皮質上皮細胞によるγδT 細胞の分化制御2014

    • Author(s)
      新田 剛、室 龍之介、新田 幸子、小田 浩代、鈴木 春巳
    • Organizer
      Kyoto T Cell Conference(KTCC) 第24回学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Differential function of two CABIT domains in Themis2013

    • Author(s)
      Toshiyuki Okada, Takeshi Nitta, Hiroyo Oda, Michael S patrick and Harumi Suzuki
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Research-status Report
  • [Presentation] Cortical thymic epithelial cells control conventional and innate T cell development2013

    • Author(s)
      Takeshi Nitta, Ryunosuke Muro, Hiroyo Oda,Shigeo Murata, Harumi Suzuki
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] A non-synonymous SNP variant of RhoH reduces TCR mediated signal transducion via proteasomal degradation2013

    • Author(s)
      Norimasa Tamehiro, Hiroyo Oda, Harumi Suzuki
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2013 Research-status Report
  • [Presentation] Themis CABIT domains exert distinct functions in thymocyte positive selection2013

    • Author(s)
      Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Hiroyo Oda, Michael S Patrick and Harumi Suzuki
    • Organizer
      15th ICI(International Congress of Immunology)
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi