Function of IELs in the development of IBD.
| Project/Area Number |
25871164
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Digestive surgery
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
ODA Hiroyo 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 (10450595)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 非典型T細胞 / 胸腺特異的遺伝子 / 自己免疫 / T細胞特異的遺伝子 / 腸炎 / プロテオミクス / T細胞 / IEL / 胸腺特異的遺伝子群 / 分化 / 誘導型腸炎 |
|---|
| Outline of Final Research Achievements |
Dysregulation of immune response plays important roles in the pathogenesis of IBD.
To understand the role of T cells in IBD, we focused on the function of T cell specific genes (ISC1~13) in the development and function of T cells.
We newly identified 4 candidate proteins that can associate with ISC4 in T cells.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells.2015
Author(s)
Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
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Journal Title
EMBO Rep.
Volume: なし
Issue: 5
Pages: 638-653
DOI
Related Report
Peer Reviewed
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[Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.2015
Author(s)
Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y,T Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H.
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Journal Title
EMBO Rep
Volume: 16
Pages: 638-53
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.2013
Author(s)
Jin HY, Oda H, Lai M, Skalsky RL, Bethel K, Shepherd J, Kang SG, Liu WH, Sabouri-Ghomi M, Cullen BR, Rajewsky K, Xiao C.
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Journal Title
EMBO J
Volume: 32
Issue: 17
Pages: 2377-2391
DOI
Related Report
Peer Reviewed
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