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Circulating fatty acids as markers of arteriosclerosis in Sri Lanka and Japan

Research Project

Project/Area Number 25871168
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Epidemiology and preventive medicine
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition (2016)
National Center for Global Health and Medicine (2013-2015)

Principal Investigator

KUROTANI Kayo  国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 栄養教育研究部, 室長 (50610739)

Research Collaborator MIZOUE Tetsuya  国立研究開発法人国立国際医療研究センター, 国際医療協力局, 科長 (60269074)
SATO Masao  九州大学, 農学研究院, 教授 (90294909)
NONAKA Daisuke  琉球大学, 医学部, 准教授 (00538275)
NANRI Akiko  国立研究開発法人国立国際医療研究センター, 国際医療協力局, 室長 (80523646)
KUWAHARA Keisuke  帝京大学, 大学院公衆衛生学研究科, 助教 (70635226)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords脂肪酸 / 動脈硬化 / CAVI / 日本 / スリランカ / 国際比較 / 日本人 / スリランカ人 / 飽和脂肪酸 / 多価不飽和脂肪酸 / 奇数鎖 / 偶数鎖 / 脂肪酸組成
Outline of Final Research Achievements

We compared the fatty acid composition between Sri Lankan and Japanese patients with diabetes, dyslipidemia, or hypertension. We found that the mean concentration of circulating myristic acid (14:0) was much higher in Sri Lankan patients than that in Japanese patients. This finding might reflect on the fact that coconut oil is rich in myristic acid (14:0). Additionally, we found that the concentrations of circulating linoleic acid (18:2 n-6), α-linolenic acid (18:3 n-3), and eicosapentaenoic acid (20:5 n-3) were higher in Japanese patients than those in Sri Lankan patients. The major sources of these fatty acids were vegetable oils and fish, which are consumed more in Japan than in Sri Lanka. We also examined the association of circulating fatty acid composition with arterial stiffness in each country. The odd-chain saturated fatty acids (15:0+17:0) might be inversely associated with arteriosclerosis in Sri Lanka.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (16 results)

All 2017 2015 2014 2013

All Journal Article (10 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results) Presentation (6 results)

  • [Journal Article] 世界の現場で見えてきたこと フィールドワーカーがみた“学校保健” 第5回 スリランカにおける学校を中核とした健康増進活動の普及の試み2015

    • Author(s)
      黒谷佳代
    • Journal Title

      健

      Volume: 43 Pages: 6-7

    • Related Report
      2014 Research-status Report
  • [Journal Article] Dietary patterns and sleep symptoms in Japanese workers: the Furukawa Nutrition and Health Study2015

    • Author(s)
      Kurotani K, Kochi T, Nanri A, Eguchi M, Kuwahara K, Tsuruoka H, Akter S, Ito R, Pham NM, Kabe I, Mizoue T
    • Journal Title

      Sleep Med

      Volume: 16 Issue: 2 Pages: 298-304

    • DOI

      10.1016/j.sleep.2014.09.017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cholesterol and egg intakes and the risk of type 2 diabetes: the Japan Public Health Center-based Prospective Study.2014

    • Author(s)
      Kurotani K, Nanri A, Goto A, Mizoue T, Noda M, Oba S, Sawada N, Tsugane S; Japan Public Health Center-based Prospective Study Group
    • Journal Title

      Br J Nutr

      Volume: 112 Issue: 10 Pages: 1036-1043

    • DOI

      10.1017/s000711451400258x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prevalence of diabetes and pre-diabetes among workers: Japan Epidemiology Collaboration on Occupational Health Study.2014

    • Author(s)
      Uehara A, Kurotani K, Kochi T et al.
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 106 Issue: 1 Pages: 118-127

    • DOI

      10.1016/j.diabres.2014.07.013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 牛肉,豚肉の過剰摂取による糖尿病発症(疫学調査結果)2014

    • Author(s)
      黒谷佳代、溝上哲也
    • Journal Title

      食肉の科学

      Volume: 55

    • NAID

      40020170472

    • Related Report
      2013 Research-status Report
  • [Journal Article] Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults2014

    • Author(s)
      K Kurotani, M Sato, Y Ejima, K Kashima, A Nanri, NM Pham, K Kuwahara, T Mizoue
    • Journal Title

      e-SPEN Journal

      Volume: 9 Issue: 1 Pages: e7-e12

    • DOI

      10.1016/j.clnme.2013.12.003

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肉類摂取と2型糖尿病発症2013

    • Author(s)
      黒谷佳代、溝上哲也、野田光彦
    • Journal Title

      Diabetes Frontier

      Volume: 24 Pages: 355-355

    • Related Report
      2013 Research-status Report
  • [Journal Article] Plant oils were associated with low prevalence of impaired glucose metabolism in Japanese workers.2013

    • Author(s)
      Kurotani K, Kochi T, Nanri A, Tsuruoka H, Kuwahara K, Pham NM, Kabe I, Mizoue T.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 5 Pages: e64758-e64758

    • DOI

      10.1371/journal.pone.0064758

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Red meat consumption is associated with the risk of type 2 diabetes in men but not in women: a Japan Public Health Center-based Prospective Study2013

    • Author(s)
      Kurotani K, Nanri A, Goto A, Mizoue T, Noda M, Oba S, Kato M, Matsushita Y, Inoue M, Tsugane S; Japan Public Health Center-based Prospective Study Group
    • Journal Title

      Br J Nutr

      Volume: 110 Issue: 10 Pages: 1910-8

    • DOI

      10.1017/s0007114513001128

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vegetable and fruit intake and risk of type 2 diabetes: Japan Public Health Center-based Prospective Study.2013

    • Author(s)
      Kurotani K, Nanri A, Goto A, Mizoue T, Noda M, Kato M, Inoue M, Tsugane S; Japan Public Health Center-based Prospective Study Group.
    • Journal Title

      Br J Nutr.

      Volume: 109 Issue: 4 Pages: 709-717

    • DOI

      10.1017/s0007114512001705

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 血清脂肪酸組成と動脈硬化との関連:スリランカと日本の国際比較2017

    • Author(s)
      黒谷佳代、Palitha Karunapema、Kapila Jayaratne、佐藤匡央、溝上哲也
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      山梨
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] メタボリックシンドロームと糖尿病発症:J-ECOHスタディ(第8報)2014

    • Author(s)
      黒谷佳代、桑原恵介、南里明子、溝上哲也、土肥誠太郎、J-ECOH研究班
    • Organizer
      第73回日本公衆衛生学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 途上国における生活習慣病の蔓延と学校での予防活動2014

    • Author(s)
      黒谷佳代、溝上哲也
    • Organizer
      第29回日本国際保健医療学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-01 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] ビタミンDサプリメントの糖代謝への影響:介入研究2014

    • Author(s)
      黒谷佳代、南里明子、桑原恵介、笹島圭太、溝上哲也
    • Organizer
      第37回日本がん疫学・分子疫学研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-13 – 2014-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 食事パターンと不眠症状の関連 ー職域栄養疫学調査ー2014

    • Author(s)
      黒谷佳代、南里明子、幸地勇、江口将史、鶴岡寛子、伊藤理恵、桑原恵介、ファムゴクミン、アクターシャミマ、加部勇、溝上哲也
    • Organizer
      第24回日本疫学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] Plant oils were associated with low prevalence of impaired glucose metabolism in Japanese workers2013

    • Author(s)
      Kurotani K, Kochi T, Nanri A, Tsuruoka H, Kuwahara K, Pham NM, Kabe I, Mizoue T
    • Organizer
      Asia Pacific Conference on Clinical Nutrition
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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