| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
MEN beta (MENb) long non-coding RNA have been identified as an essential factor for structural integrity of nuclear body paraspeckle involved in stress responses. The ability of MENb to retain several nuclear proteins in paraspeckle seems likely to contribute to formation of abnormal nuclear foci observed in neurodegenerative disorders such as Huntington’s disease; however, it remains to be elucidated. In this study, we evaluated whether MENb influences organization of nuclear foci in Huntington’s disease using model mice and stable cell lines expressing the mutant Huntingtin (mHTT) gene. The expression analysis of MENb and the localization analysis of nuclear foci derived from mHTT in vitro and in vivo suggested a poor relation between MENb and mHTT aggregations.
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