Development of prediction methods for toxicity of chemical substances based on quantitative activity-activity relationship approaches
| Project/Area Number |
25871184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental policy and social systems
Environmental impact assessment
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Jun-ichi Takeshita 国立研究開発法人産業技術総合研究所, 安全科学研究部門, 主任研究員 (60574390)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 化学物質 / ヒト健康 / 有害性推論 / QAAR（定量的活性活性相関） / 統計解析 / 遺伝子発現データ / クラスター分析 / 組合せ最適化 / 複合影響評価 / 濃度加算法 / NOEL（無毒性量） / アセスメントファクタ / リスクトレードオフ評価 |
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| Outline of Final Research Achievements |
We have developed methodologies to predict toxicity level of chemical substances to conduct a risk assessment. First, we assembled existing toxicity data in rats and mice from “Initial Risk Assessment Report,” released by Japan’s National Institute of Technology and Evaluation. We used the data to construct a training dataset, which led to the following two achievements: a) development of a statistical model to predict toxicity level of an endpoint based on the toxicity data of other endpoints, using the structural equation modeling, and b) quantification of assessment factors for each endpoint, which can be used to extrapolate toxicity level of long-term toxicity tests from that of short-term toxicity tests.
Furthermore, other than the study based on the dataset, we have developed a statistical analysis method that allows a risk assessment of combined exposure to multiple chemicals to be expressed in quantified figures.
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Report
(4 results)
Research Products
(23 results)
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[Presentation] 遺伝子発現データに基づく化学物質の類似性について2015
Author(s)
竹下潤一, 阿部亮介, 豊田章倫, 遠藤靖典, 宮本定明, 谷英典, 青木寛, 鳥村政基, 佐藤浩明, 蒲生昌志
Organizer
日本動物実験代替法学会第28回大会
Place of Presentation
ワークピア横浜, 横浜
Year and Date
2015-12-11
Related Report
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