| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
Mechanical pressure stimulation applied to the calf alters heart rate in anesthetized animals. The aim of the present study was to establish an assessment method for muscle pain in anesthetized animals by using cardiac function changes in response to muscle stimulation. Heart rate, arterial pressure and cardiac sympathetic nerve activity were recorded during experiments. Heart rate changes (increase and decrease) in response to pressure stimulation of the calf muscles were almost abolished by blocking cardiac sympathetic nerve activity. Additionally, experiments that cardiac sympathetic nerve activity were recorded revealed that nerve activity changes occurred in parallel with heart rate changes. In the calf inflamed by inflammatory substance administration, pressure stimulation-induced increases in cardiac sympathetic nerve activity and heart rate exaggerated.
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