Estabishment of dose volume constraints of organs at risk in image-guided intensity-modulated radiation therapy for prostate cancer

• Project/Area Number: 25871226
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science; Urology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: TOMITA Natsuo 愛知県がんセンター(研究所), 疫学・予防部, 研究員 (60643781)
• Research Collaborator: OZE Isao 愛知県がんセンター(研究所), 疫学・予防部, 研究員 (00584509)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 前立腺癌 / 強度変調放射線治療 / 直腸障害 / 線量制約 / 画像誘導下放射線治療 / 画像誘導放射線治療

Outline of Final Research Achievements

The availability of image-guided intensity-modulated radiation therapy is expected for prostate cancer. The late rectal toxicity is the most important problem in high-dose external beam radiation therapy for prostate cancer. Late rectal toxicity was 7.4% after image-guided intensity-modulated radiation therapy in this study. The result of this study indicates that the risk of late rectal toxicity correlates with the rectal volume exposed to high doses of image-guided intensity-modulated radiation therapy, and the percentage of the rectum covered by 70 Gy and 60 Gy are needed to keep below at least 10% and 18%, respectively.

Research Products

• [Journal Article] A case of severe hemoptysis after stereotactic body radiotherapy for peripherally located stage I non-small cell lung cancer (2015)
  • Author(s): Kimura K, Tomita N, Shimizu A, Sato Y, Makita C, Kodaira T
  • Journal Title: Jpn J Radiol Volume: 印刷中 Issue: 6 Pages: 370-374
  • DOI: 10.1007/s11604-015-0423-4
  • NAID: 50009519128
  • Peer Reviewed
• [Journal Article] Tomita N, Kodaira T, Teshima T, Ogawa K, Kumazaki Y, Yamauchi C, Toita T, Uno T, Sumi M, Onishi H, Kenjo M, Nakamura K. (2014)
  • Author(s): Tomita N, Kodaira T, Teshima T, Ogawa K, Kumazaki Y, Yamauchi C, Toita T, Uno T, Sumi M, Onishi H, Kenjo M, Nakamura K.
  • Journal Title: Jpn J Clin Oncol Volume: 44 Issue: 6 Pages: 579-86
  • DOI: 10.1093/jjco/hyu041
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Efficacy of Alternating Chemoradiotherapy by Conformal Radiotherapy Combined with Intracavitary Brachytherapy for High-risk Cervical Cancer (2014)
  • Author(s): Kimiko Hirata, Takeshi Kodaira, Natsuo Tomita, Yukihiko Ohshima, Junji Ito, Hiroyuki Tachibana, Toru Nakanishi, Nobukazu Fuwa
  • Journal Title: Jpn J Clin Oncol Volume: 印刷中 Issue: 6 Pages: 556-563
  • DOI: 10.1093/jjco/hyu048
  • Peer Reviewed
• [Journal Article] Preliminary analysis of risk factors for late rectal toxicity after helical tomotherapy for prostate cancer (2013)
  • Author(s): Tomita N, Soga N, Ogura Y, Hayashi N, Shimizu H, Kubota T, Ito J, Hirata K, Ohshima Y, Tachibana H, Kodaira T
  • Journal Title: J Radiat Res Volume: 54 Issue: 5 Pages: 919-924
  • DOI: 10.1093/jrr/rrt025
  • Peer Reviewed
• [Journal Article] Alternating chemoradiotherapy in patients with nasopharyngeal cancer: prognostic factors and proposal for individualization of therapy (2013)
  • Author(s): Goto Y, Kodaira T, Fuwa N, Mizoguchi N, Nakahara R, Nomura M, Tomita N, Tachibana H
  • Journal Title: J Radiat Res Volume: 54 Issue: 1 Pages: 98-107
  • DOI: 10.1093/jrr/rrs071
  • Peer Reviewed
• [Journal Article] Clinical outcome and patterns of recurrence of head and neck squamous cell carcinoma with a limited field of postoperative radiotherapy (2013)
  • Author(s): Goto Y, Kodaira T, Furutani K, Tachibana H, Tomita N, Ito J, Hanai N, Ozawa T, Hirakawa H, Suzuki H, Hasegawa Y
  • Journal Title: Jpn J Clin Oncol Volume: 43 Issue: 7 Pages: 719-725
  • DOI: 10.1093/jjco/hyt066
  • Peer Reviewed
• [Presentation] 当院における前立腺癌放射線治療後PSA再発の予後に関する検討 (2015)
  • Author(s): 富田夏夫
  • Organizer: 第157回日本医学放射線学会中部地方会
  • Place of Presentation: 名古屋大学（愛知県名古屋市)
  • Year and Date: 2015-02-01 – 2015-02-02
• [Presentation] 当院における前立腺癌に対する放射線治療の中期成績 (2014)
  • Author(s): 富田夏夫
  • Organizer: 日本放射線腫瘍学会第27回学術大会
  • Place of Presentation: パシフィコ横浜会議センター（神奈川県横浜市）
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Evaluation of Urinary Outcomes by International Prostate Symptom Scores (IPSS) in Intensity Modulated Radiation Therapy Combined with Androgen Deprivation Therapy for Prostate Cancer (2013)
  • Author(s): 富田 夏夫
  • Organizer: 2014年度米国放射線腫瘍学会
  • Place of Presentation: ジョージア世界会議センター（米国ジョージア州アトランタ）
• [Presentation] 前立腺癌に対する内分泌治療併用強度変調放射線治療におけるIPSSによる排尿機能の評価 (2013)
  • Author(s): 富田 夏夫
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] 当院における前立腺癌に対する放射線治療の中期成績
  • Author(s): 富田 夏夫
  • Organizer: 日本医学放射線学会中部地方会
  • Place of Presentation: 愛知県がんセンター中央病院（愛知県名古屋市）