The elucidation of inflammatory response mechanism in the hyperoxic condition during extracorporeal circulation
Project/Area Number |
25871231
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular surgery
General surgery
|
Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
FUJII Yutaka 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (20589303)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 体外循環 / 高酸素 / 活性酸素 / 炎症反応 / サイトカイン / 補助循環 / 人工心肺 / 活性酸素種 |
Outline of Final Research Achievements |
Systemic inflammatory responses in patients receiving cardiac surgery supported by cardiopulmonary bypass (CPB) significantly contribute to CPB-associated morbidity and mortality. We hypothesized that hyperoxia insufflation aggravates the inflammatory responses and organ damage during CPB. To verify this hypothesis, we investigated the inflammatory responses at high and normal levels of arterial pressure of oxygen (PaO2) in the rat CPB model. In this study suggest that it is better to avoid too much oxygen insufflation for attenuating organ damage associated with the superoxide production and inflammatory responses during CPB.
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Report
(3 results)
Research Products
(16 results)