| Project/Area Number |
25882007
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
IMAI Tomoko 筑波大学, スポーツR&Dコア, 研究員 (50613593)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 気道内IGF-1 / 高強度レジスタンス運動 / 気道炎症 / 呼気凝縮液 / レジスタンス運動 / IGF-1 |
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| Outline of Final Research Achievements |
Insulin-like growth factor-1 (IGF-1) is essential for skeletal muscle hypertrophy and development. IGF-I is also known to be involved in airway remodeling, constriction, and inflammation. The aim of present study was to determine whether airway-derived IGF-1 is regulated by acute high-intensity exercise, so that we can elucidate the mechanism of exercise-induced asthma (EIA) response.
In young healthy men after acute high-intensity exercise, we could not detect for airway derived IGF-1 but serum IGF-1 significantly increased. In 5 individuals, the amount of exhaled nitrous oxide increased after acute high-intensity exercise. The effects of airway stress caused by acute high-intensity exercise requires further investigation.
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