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The effects of exercise on airway derived IGF-1

Research Project

Project/Area Number 25882007
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionUniversity of Tsukuba

Principal Investigator

IMAI Tomoko  筑波大学, スポーツR&Dコア, 研究員 (50613593)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords気道内IGF-1 / 高強度レジスタンス運動 / 気道炎症 / 呼気凝縮液 / レジスタンス運動 / IGF-1
Outline of Final Research Achievements

Insulin-like growth factor-1 (IGF-1) is essential for skeletal muscle hypertrophy and development. IGF-I is also known to be involved in airway remodeling, constriction, and inflammation. The aim of present study was to determine whether airway-derived IGF-1 is regulated by acute high-intensity exercise, so that we can elucidate the mechanism of exercise-induced asthma (EIA) response.
In young healthy men after acute high-intensity exercise, we could not detect for airway derived IGF-1 but serum IGF-1 significantly increased. In 5 individuals, the amount of exhaled nitrous oxide increased after acute high-intensity exercise. The effects of airway stress caused by acute high-intensity exercise requires further investigation.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] 一過性レジスタンス運動における呼気一酸化窒素の応答2014

    • Author(s)
      今井智子, 曽根良太, 渡部厚一
    • Organizer
      第69回 日本体力医学会大会
    • Place of Presentation
      長崎大学(長崎県 長崎市)
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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