Risk factors for type 2 diabetes among individuals with impaired insulin secretion

• Project/Area Number: 25882019
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: MORIMOTO Akiko 滋賀医科大学, 医学部, 講師 (90710377)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: インスリン分泌不全 / インスリン抵抗性 / 糖尿病 / 危険因子 / 2型糖尿病 / コホート研究

Outline of Final Research Achievements

This study included individuals without diabetes at baseline who underwent comprehensive medical check-ups at Saku Central Hospital. Moderate and large increases in homeostasis model assessment of insulin resistance (HOMA-IR) had a strong impact on the development of type 2 diabetes regardless of baseline HOMA-IR values among individuals with impaired insulin secretion in this Japanese population. Moreover, metabolic factors had a strong impact on the development of type 2 diabetes among individuals with impaired insulin secretion, compared with individuals with insulin resistance.

Research Products

• [Journal Article] Increase in Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) had a strong impact on the development of type 2 diabetes in Japanese individuals with impaired insulin secretion: class FormattedString { value: The Saku study } (2014)
  • Author(s): Morimoto A, Tatsumi Y, Soyano F, Miyamatsu N, Sonoda N, Godai K, Ohno Y, Noda M, Deura K
  • Journal Title: PLOS ONE Volume: 9 Issue: 8 Pages: e105827-e105827
  • DOI: 10.1371/journal.pone.0105827
  • URL: https://localhost/en/publications/b4c6ed7a-9876-4e4c-b306-25a3663e1426
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between smoking and post-load plasma glucose levels using a 75-g oral glucose tolerance test: class FormattedString { value: The Saku Study } (2014)
  • Author(s): Morimoto A, Tatsumi Y, Miyamatsu N, Sonoda N, Deura K
  • Journal Title: Diabetes Research and Clinical Practice Volume: 106 Issue: 2 Pages: e38-e40
  • DOI: 10.1016/j.diabres.2014.08.013
  • URL: https://localhost/en/publications/6af0f4a4-afd1-4d6c-b8e1-be1615083001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact of impaired insulin secretion and insulin resistance on the incidence of diabetes in a Japanese cohort. Reply to Yamauchi K and Aizawa T [letter] (2013)
  • Author(s): Morimoto A, Tatsumi Y, Deura K, Miyamatsu N, Noda M, Watanabe S
  • Journal Title: Diabetologia Volume: 56 Issue: 11 Pages: 2546-2547
  • DOI: 10.1007/s00125-013-3068-9
  • Peer Reviewed
• [Presentation] インスリン分泌不全の有無によるHOMA-IR 増加が糖尿病発症に及ぼす影響：佐久研究 (2014)
  • Author(s): 森本明子，辰巳友佳子，出浦喜丈，征矢野文恵，宮松直美，大野ゆう子，水野正一，渡邊昌
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 日立システムズホール仙台