| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Plasminogen activator inhibitor-1 (PAI-1), a major component of the fibrinolytic system. Recently, Tang et al. reported that PAI-1 played roles on promoting breast cancer(Tang et al., 2013). Meanwhile, exposure to the nocturnal light disrupts many biological systems, and Aoshima et al showed that the nocturnal light exposure (1 hour) induced PAI-1 gene expression in mice(Aoshima et al., 2014). Then, it is hypothesized that the nocturnal light exposure promotes breast cancer progression by induction of PAI-1, and that this system might be possibly prevented by administration of functional food factor. Thus, in this study, the effects of nocturnal light exposure on PAI-1 were examined. At the dark period, C3H/He mice were exposed to light (250 lux). In plasma of mice exposed to light, PAI-1 secretion was induced. And nocturnal light exposure altered hepatic expression of clock genes.
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