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The effects of patterned electrical stimulation on recovery of locomotor function and understanding the neural basis of functional recovery

Research Project

Project/Area Number 25882029
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKeio University

Principal Investigator

YAMAGUCHI Tomofumi  慶應義塾大学, 医学部, 特任助教 (20594956)

Research Collaborator TAKAHASHI Yoko  慶應義塾大学, 大学院医学研究科
Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords電気刺激 / 随意運動 / 脊髄反射 / 相反性抑制 / 可塑性 / 歩行 / 脳卒中 / リハビリテーション / 電気刺激療法 / 下肢 / 脊髄相反性抑制 / 反射 / 機能回復
Outline of Final Research Achievements

The present study showed the combined patterned electrical stimulation with voluntary contraction (PES+VC) can increase the reciprocal inhibition (RI) with 5 min, while it took 20 minutes to induce a significant increase of RI with PES alone and VC alone. In addition, we found that the after-effects of PES+VC on the RI persisted longer compared with PES alone and VC alone after 20 min intervention. These effects were observed in patients with chronic stroke. It has been reported that reduction in the RI is related to abnormal muscle coactivation during locomotion in patients with stroke. Our result provides further support for the idea that the application of PES to the affected leg during locomotion might be a useful adjuvant strategy for functional recovery of locomotion in patients with stroke.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (32 results)

All 2015 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (16 results) (of which Invited: 1 results) Book (6 results)

  • [Journal Article] 最近の臨床神経生理学-末梢神経における治療への応用-2015

    • Author(s)
      山口智史
    • Journal Title

      総合リハビリテーション

      Volume: 43

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Increasing corticospinal excitability in the antagonist muscle during muscle relaxation with a tracking task2015

    • Author(s)
      Yoshida N,Yamaguchi T,Saito K,Tanabe S,Sugawara K
    • Journal Title

      Somatosensory & Motor Research

      Volume: 未確定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機能回復に対するリハビリテーションの新しい流れ2014

    • Author(s)
      藤原俊之,山口智史
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 24 Pages: 451-454

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Dual-hemisphere transcranial direct current stimulation improves performance in a tactile spatial discrimination task.2014

    • Author(s)
      Fujimoto S, Yamaguchi T, Otaka Y, Kondo K, Tanaka S
    • Journal Title

      Clinical neurophysiology

      Volume: 125 Issue: 8 Pages: 1669-1674

    • DOI

      10.1016/j.clinph.2013.12.100

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Time-dependent changes in motor cortical excitability by electrical stimulation combined with voluntary drive2014

    • Author(s)
      Sugawara K,Yamaguchi T,Tanabe S,Suzuki T,Saito K,Higashi T
    • Journal Title

      NeuroReport

      Volume: 25 Issue: 6 Pages: 404-409

    • DOI

      10.1097/wnr.0000000000000108

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploration of the Physical Functions Related to the Gait Ability of Subacute Stroke Patients using Canonical Correlation Analysis2014

    • Author(s)
      藤本修平,小宅一彰,山口智史,田辺茂雄,近藤国嗣,大高洋平
    • Journal Title

      Rigakuryoho Kagaku

      Volume: 29 Issue: 4 Pages: 627-631

    • DOI

      10.1589/rika.29.627

    • NAID

      130004690887

    • ISSN
      1341-1667, 2434-2807
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined effect of motor imagery and peripheral nerve electrical stimulation on the motor cortex2013

    • Author(s)
      Saito K, Yamaguchi T, Yoshida N, Tanabe S, Kondo K, Sugawara S
    • Journal Title

      Experimental Brain Research

      Volume: (in press) Issue: 3 Pages: 333-342

    • DOI

      10.1007/s00221-013-3513-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of transcutaneous spinal DC stimulation on plasticity of the spinal circuits and corticospinal tracts in humans2013

    • Author(s)
      Yamaguchi T, Fujimoto S, Otaka Y, Tanaka S
    • Journal Title

      Proceedings of the 6th international IEEE EMBS neural engineering conference

      Volume: 1 Pages: 275-278

    • DOI

      10.1109/ner.2013.6695925

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specifications of an electromyogram-driven neuromuscular stimulator for upper limb functional recovery2013

    • Author(s)
      Muraoka Y, Tanabe S, Yamaguchi T, Takeda K
    • Journal Title

      Conference proceedings of IEEE Engineering in Medicine and Biology Society

      Volume: 1 Pages: 277-280

    • DOI

      10.1109/embc.2013.6609491

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 人工膝関節置換術後患者における術創部周囲の皮膚可動性2012

    • Author(s)
      荒川武士,上原信太郎,山口智史,伊藤克浩
    • Journal Title

      Congress of the Japanese Physical Therapy Association

      Volume: 2011 Issue: 0 Pages: Ca0919-Ca0919

    • DOI

      10.14900/cjpt.2011.0.Ca0919.0

    • NAID

      130004692966

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 基礎的理学療法研究から臨床応用への展開2015

    • Author(s)
      山口智史
    • Organizer
      第50回日本理学療法学術大会(招待講演)
    • Place of Presentation
      東京国際フォーラム(東京都千代田区))
    • Year and Date
      2015-06-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 神経科学的知見に基づいた中枢神経損傷後の歩行機能再獲得への挑戦2015

    • Author(s)
      山口智史
    • Organizer
      第50回日本理学療法学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区))
    • Year and Date
      2015-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 学習課題中の体性感覚電気刺激が運動学習と半球間抑制に与える影響2015

    • Author(s)
      山口智史,菅原憲一,前田和平,田辺茂雄,田中悟志,里宇明元
    • Organizer
      第50回日本理学療法学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区))
    • Year and Date
      2015-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 回復期脳卒中者の歩行障害に対するペダリング運動と電気刺激療法の併用効果:多施設共同ランダム化比較試験2015

    • Author(s)
      山口智史,生野公貴,渕上健,小林啓晋,藤川加奈子,小山総市朗,河口沙織,北裏真己,前田和平,松永玄,里宇明元
    • Organizer
      第52回日本リハビリテーション医学会学術集会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pedaling exercise combined with sensory electrical stimulation improves gait performance in subacute stroke patients: a multicenter,sham-controlled randomized controlled trial2015

    • Author(s)
      Yamaguchi T,Ikuno K,Fuchigami K,Koyama S,Fujikawa K,Kobayashi H,Kitaura M,Matsunaga H,Liu M
    • Organizer
      The World Confederation for Physical Therapy 2015
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre(Suntec City, Singapore)
    • Year and Date
      2015-05-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effects of different intensities of anodal tDCS on spinal plasticity induced by patterned electrical stimulation2015

    • Author(s)
      Yamaguchi T,Fujiwara T,Tsai Y,Liu M
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore EXPO Convention and Exhibition Centre(Suntec City, Singapore)
    • Year and Date
      2015-03-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体性感覚刺激が運動学習と半球間抑制に与える影響2014

    • Author(s)
      山口智史,菅原憲一,前田和平,田辺茂雄,里宇明元
    • Organizer
      第44回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ング課題中の末梢神経刺激が運動学習と半球間抑制に与える影響2014

    • Author(s)
      山口智史,菅原憲一,前田和平,田辺茂雄,田中悟志,里宇明元
    • Organizer
      第1回 日本基礎理学療法学会学術集会・ 日本基礎理学療法学会 第4回学術大会 合同学会
    • Place of Presentation
      名古屋学院大学名古屋キャンパス白鳥学舎(愛知県名古屋市)
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 治療的電気刺激が運動学習と半球間抑制に与える影響2014

    • Author(s)
      山口智史,菅原憲一,前田和平,田辺茂雄,田中悟志,里宇明元
    • Organizer
      第22回日本物理療法学会学術大会
    • Place of Presentation
      信州大学医部附属病院4階 信州大学医部附属病院4階 信州大学医部附属病院4階 信州大学医部附属病院4階 信州大学医部附属病院4階(長野県松本市)
    • Year and Date
      2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 運動イメージが脊髄抑制性介在ニューロンに与える影響2014

    • Author(s)
      山口智史,藤原俊之,田辺茂雄,里宇明元
    • Organizer
      第49回日本理学療法学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combined effects of pedaling exercise and sensory electrical stimulation on gait performance in patients with subacute stroke: a multicenter,sham-controlled randomized controlled trial2014

    • Author(s)
      Yamaguchi T,Ikuno K,Fuchigami K,Koyama S,Fujikawa S,Kobayashi H,Kitaura M,Matsunaga H,Liu M
    • Organizer
      8th World Congress for NeuroRehabilitation
    • Place of Presentation
      Istanbul Lütfi Kırdar International Convention & Exhibition Center(Istanbul, Turkey)
    • Year and Date
      2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combined effects of pedaling exercise and sensory electrical stimulation on gait performance in patients with subacute stroke: a multicenter, sham-controlled randomized controlled trial2014

    • Author(s)
      Yamaguchi T, Ikuno K, Fuchigami K, Koyama S, Fujikawa S, Kobayashi H, Kitaura M, Matsunaga H, Liu M
    • Organizer
      8th World Congress for NeuroRehabilitation,
    • Place of Presentation
      Istanbul
    • Related Report
      2013 Annual Research Report
  • [Presentation] The combined effects of anodal tDCS and patterned electrical stimulation on spinal inhibitory interneurons and motor function among patients with incomplete spinal cord injury.2014

    • Author(s)
      Yamaguchi T, Fujiwara T, Tsai Y, Tang S, Liu M
    • Organizer
      30th International Congress on Clinical Neurophysiology
    • Place of Presentation
      Berlin
    • Related Report
      2013 Annual Research Report
  • [Presentation] Attention modulates plasticity in human motor cortex2013

    • Author(s)
      Yamaguchi T, Tanaka S, Moriya S, Otaka Y
    • Organizer
      Neuroscience2013
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of transcutaneous spinal DC stimulation on plasticity of the spinal circuits and corticospinal tracts in humans2013

    • Author(s)
      Yamaguchi T, Fujimoto S, Otaka Y, Tanaka S
    • Organizer
      6th international IEEE EMBS Conference on Neural Engineering
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel strategy of peripheral nerve stimulation for the recovery of locomotion among patients with central nervous system lesions2013

    • Author(s)
      Yamaguchi T
    • Organizer
      WCPT-AWP & ACPT 2013
    • Place of Presentation
      Taichung
    • Related Report
      2013 Annual Research Report
  • [Book] リハビリテーションに役立つ臨床神経生理学(正門由久,村岡慶裕,牛場潤一 編集)2015

    • Author(s)
      齊藤慶,山口智史(題目:電気刺激療法の応用)
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 臨床思考を踏まえる理学療法プラクティス 感覚入力で挑む(斎藤秀之,加藤浩,金子文成 編集)2015

    • Author(s)
      山口智史(題目:末梢からの求心性入力-電気刺激-)
    • Publisher
      文光堂
    • Related Report
      2014 Annual Research Report
  • [Book] 神経科学の最新動向とリハビリテーション(里宇明元,牛場潤一 監修)2015

    • Author(s)
      山口智史(題目;FES,ペダリング,電気刺激)
    • Publisher
      医歯薬出版
    • Related Report
      2014 Annual Research Report
  • [Book] エビデンスに基づく理学療法 第2版 (内山靖 編集)2015

    • Author(s)
      山口智史(題目:リハビリテーションにおけるEBM)
    • Publisher
      医歯薬出版
    • Related Report
      2014 Annual Research Report
  • [Book] 自信がもてる!リハビリテーション臨床実習(里宇明元 監修)2015

    • Author(s)
      山口智史(編集者、実習の予習をしよう編、応用力をつけよう編)
    • Total Pages
      248
    • Publisher
      医歯薬出版
    • Related Report
      2014 Annual Research Report
  • [Book] 老年薬学-リハビリテーション2014-2014

    • Author(s)
      山口智史(編集者、日常生活と介助、高齢者のうつ病と運動療法など)
    • Total Pages
      165
    • Publisher
      慶應義塾大学出版会
    • Related Report
      2014 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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