Cell stress response by the metal exposure for dental repair materials development

• Project/Area Number: 25882035
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Waseda University
• Principal Investigator: KARUBE Hiroyo 早稲田大学, 理工学術院, 助教 (70318913)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯科用修復材料 / 金属曝露 / 細胞ストレス応答 / バナジン酸ナトリウム / 象牙芽細胞様細胞株

Outline of Final Research Achievements

It is said "dental health" is an important part of the body to maintain its "health" of the human. As for the development of dental repair materials, it has an essential role in improving treatment in the field of dentistry. Therefore, we paid close attention to the "dental metal" in this study. The use of these "dental metals" are anticipated as the prospective dental repair materials in the future. We have evaluated the safety in cells by exposing metal to the cells of teeth then examined safety assessment for the contribution and the clinical application to the development of the new material of dental repair materials.

Research Products

• [Remarks] 早稲田大学 梅津研究室