The effects of exercise training on the level of adropin

Research Project

Project/Area Number	25882039
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Applied health science
Research Institution	Doshisha University
Principal Investigator	Hieda Mutsuko 同志社大学, スポーツ健康科学部, 助教 (70707455)
Project Period (FY)	2013-08-30 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	運動トレーニング / 血管内皮機能
Outline of Final Research Achievements	Adropin is a new peptide hormone that regulates lipid and glucose homeostasis. Also, adropin plays important roles in regulating endothelial functions. This study aims to evaluate whether exercise affects the level of adropin in obese rats. The Zucker fatty rats were randomly assigned to one of two groups: an exercise-trained group (ZFE) and a sedentary one (ZFC). ZFE was trained on a treadmill for 5days/week for 6 weeks. In addition, the Zucker lean rats were subjected to identical sedentary (ZLC). Rats were sacrificed 24h after the last training period, and their blood and some of their organs were collected. Body weight was lower in the ZFE compared to the ZFC. Plasma adropin was the highest in the ZFE among three groups. The findings of this study suggest that exercise training would increase adropin concentration in obese rats.