| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Electronic-structure calculations with the molecular orbital method as well as molecular dynamics simulations have been performed to elucidate the mechanisms of ultrafast nonradiative decay in nucleic acid bases and their multimers, which might be responsible for the photostability of DNA, at the molecular level. As a result, it has been found that photophysical behavior of uric acid and thymine is largely affected by a small number of hydrogen bonds. This finding suggests that hydrogen bond may play an essential role also in the photochemical processes of nucleobase multimers, which include interbase hydrogen bonds.
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