| Project/Area Number |
25888012
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
ASANO Keisuke 京都大学, 工学(系)研究科(研究院), 助教 (90711771)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 有機分子触媒 / 不斉合成 / アシルアンモニウム / サルファマイケル付加 / ラクトン / 1,5-ベンゾチアゼピン / 複素環合成 / 医薬候補化合物 / 環化付加 / ライブラリー合成 / 二官能性有機分子触媒 / 生体酵素 / 水素結合 / 共有結合性相互作用 / ラクトン合成 |
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| Outline of Final Research Achievements |
Utilizing α,β-unsaturated acylammonium intermediates generated from carboxylic acid derivatives and tertiary amine catalysts, we accomplished the facile asymmetric syntheses of heterocyclic compounds through the enantioselective introduction of a sulfur atom at the β-position of carboxylic acid derivatives via sulfa-Michael addition. This method enabled the catalytic enantioselective syntheses of β-mercaptolactones and 1,5-benzothiazepines. These heterocycles are highly important as candidates of pharmaceutical agents, and this research can be expected to contribute to the field of drug discovery.
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