| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The self-assembled membranes of amphiphilic molecules were designed with phospholipid, cholesterol, fatty acid, surfactant, etc., and were applied to the molecular recognition and conversion processes. The phospholipid-modified Au nanoparticles (Au@PL) were developed for high-sensitive analysis of the dynamic behaviors of membranes. Au@PL showed the enhanced Raman spectra with >100-fold larger intensity. With fluorescent prove analysis, various kinds of vesicle membranes could be characterized. Using such a designed vesicle, the recognition and conversion processes carried out. In the case of 1,3-dipolarcycloaddition reaction, the hydrophobic substrate (BNO) and the hydrophilic substrate (EMI) were accumulated on the membrane, where the membrane surface was dehydrated due to the distribution of BNO. The relative reaction constant increased to 2.7-fold, indicating that the membrane surface can applied to the recognition and conversion processes.
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