Mechanical analysis of three-dimensional multicellular dynamics during organogenesis
| Project/Area Number |
25889070
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Materials/Mechanics of materials
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OKUDA Satoru 独立行政法人理化学研究所, 多細胞システム形成研究センター, 研究員 (80707836)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 組織形態形成 / 多細胞ダイナミクス / 粘性効果 / RNRモデル / 粗視化モデル / 計算力学 / バイオメカニクス / 発生生物 / ＲＮＲモデル |
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| Outline of Final Research Achievements |
This study aims to reveal mechanical states of multicellular system in three-dimensional organogenesis using computational simulations of the reversible network reconnection (RNR) model. Because the displacement velocity of the whole tissue is assumed to be small in the RNR model, the applicability of the model is limited to small deformations. Therefore, to apply the RNR model to simulating dynamic organogenesis, we improved the RNR model by taking account of the effects of local velocity on deformations. Moreover, by simulating the process of epithelial growth within viscous liquid using the proposed model, we analyzed the effects of extracellular viscosity on epithelial morphogenesis.
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Report
(3 results)
Research Products
(12 results)
