Identification of surrogate plasma markers for early diagnosis of Alzheimer's disease

Research Project

Project/Area Number	25889072
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Biofunction/Bioprocess
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	TSUKAKOSHI Kaori 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (20708474)
Project Period (FY)	2013-08-30 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	アルツハイマー病 / 早期診断 / バイオマーカー / トランスレーショナルリサーチ / アプタマー
Outline of Final Research Achievements	Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Abeta) and tau deposition. It is revealed that Abeta plaques emerge first in progression of AD; therefore the blood-based biomarker to detect Abeta deposition is useful for early diagnosis of AD. We performed screening of blood-based biomarkers in AD model mice that we recently developed by using 2D-DIGE and identified four marker candidate proteins. We are validating those candidates by ELISA and aptamer-based assay.

Report

(3 results)