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Identification of surrogate plasma markers for early diagnosis of Alzheimer's disease

Research Project

Project/Area Number 25889072
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

TSUKAKOSHI Kaori  独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (20708474)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアルツハイマー病 / 早期診断 / バイオマーカー / トランスレーショナルリサーチ / アプタマー
Outline of Final Research Achievements

Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Abeta) and tau deposition. It is revealed that Abeta plaques emerge first in progression of AD; therefore the blood-based biomarker to detect Abeta deposition is useful for early diagnosis of AD.
We performed screening of blood-based biomarkers in AD model mice that we recently developed by using 2D-DIGE and identified four marker candidate proteins. We are validating those candidates by ELISA and aptamer-based assay.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] アミロイドβ代謝の分子機構から紐解くアルツハイマー病2014

    • Author(s)
      塚越かおり、西道隆臣
    • Journal Title

      生体の科学

      Volume: 65(1) Pages: 69-73

    • Related Report
      2013 Annual Research Report
  • [Presentation] POST-TRANSLATIONAL MODIFICATION(S) OF TAU PROTEIN IN APP KNOCK-IN MICE2015

    • Author(s)
      K. Tsukakoshi, J. Takano, R. Fujioka, E. Hosoki, T. Saito, A. Takashima and T.C. Saido
    • Organizer
      ADPD2015
    • Place of Presentation
      Acropolis 1, Nice, France
    • Year and Date
      2015-03-18 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] APP・タウダブルノックインマウスの作製2014

    • Author(s)
      塚越かおり、斉藤貴志、西道隆臣
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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