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Elucidation of local neural networks for supporting while limiting cognitive functions

Research Project

Project/Area Number 25890001
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Tokyo (2014)
Hokkaido University (2013)

Principal Investigator

MATSUSHIMA Ayano  東京大学, 医学(系)研究科(研究院), 特任助教 (10706740)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords高次機能 / ワーキングメモリ / 選択的注意 / DNA組み替え / アデノ関連ウイルス
Outline of Final Research Achievements

Humans can remember or attend to multiple moving objects at the same time. The number of objects that can be held in memory or attention is known to be larger when visual stimuli are presented bilaterally rather than presented unilaterally. To elucidate the underlying neuronal mechanism, we trained monkeys with two cognitive tasks; multiple memory-guided saccade task and multiple object tracking task. We found that neurons in the lateral prefrontal cortex exhibited greater activity for bilateral than for unilateral stimuli. Considering the inherent, anatomical separation of contralateral and ipsilateral visual processing, our data might reflect the stronger interaction of mnemonic and attentional signals for multiple objects presented unilaterally than those presented bilaterally.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (7 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] 限られた認知能力とその効率的な分配に関わる神経基盤 Neuronal Correlates of Efficient but Limited Capacity of Cognition.2015

    • Author(s)
      松嶋 藻乃
    • Journal Title

      日本神経回路学会誌

      Volume: 22(1) Pages: 03-15

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Differential neuronal representation of spatial attention dependent on relative target locations during multiple object tracking.2014

    • Author(s)
      Matsushima, A. & Tanaka, M.
    • Journal Title

      J. Neurosci.

      Volume: 34 Issue: 30 Pages: 9963-9969

    • DOI

      10.1523/jneurosci.4354-13.2014

    • NAID

      120005537462

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors2014

    • Author(s)
      Nonaka M, Kim R, Sharry S, Matsushima A, Takemoto-Kimura S, Bito H
    • Journal Title

      Neurobiology of Learning and Memory

      Volume: 115 Pages: 21-29

    • DOI

      10.1016/j.nlm.2014.08.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Different neuronal computations of spatial working memory for multiple locations within versus across visual hemifields.2014

    • Author(s)
      Matsushima, A. & Tanaka, M.
    • Journal Title

      J. Neurosci.

      Volume: 34 Issue: 16 Pages: 5621-5626

    • DOI

      10.1523/jneurosci.0295-14.2014

    • NAID

      120005476076

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Neuronal correlates of efficient but limited capacity of cognition.2014

    • Author(s)
      Matsushima A
    • Organizer
      Seminar Talk
    • Place of Presentation
      IST Austria (Klosterneuburg)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 複数の物体に対する注意の配分―サル前頭前野の神経活動による検討2013

    • Author(s)
      松嶋藻乃, 田中真樹
    • Organizer
      生理学会 北海道地方会
    • Place of Presentation
      旭川医大(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Distinct neuronal mechanisms for remembering multiple locations within vs. across visual hemifields.2013

    • Author(s)
      Matsushima A. and Tanaka M.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San diego convention center (San Diego)
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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