Molecular mechanism of temporal AMPA-type glutamate receptor internalization during hippocampal long-term potentiation
| Project/Area Number |
25890009
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyoto University |
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Principal Investigator |
TANAKA Hiromitsu 京都大学, 理学(系)研究科(研究院), 助教 (30705447)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 神経科学 / 分子生物学 / ライブイメージング / シナプス可塑性 / 長期増強 / 長期抑圧 / グルタミン酸受容体 / 全反射顕微鏡 / 細胞生物学 / 海馬長期増強現象 / AMPA型グルタミン酸受容体 / シナプス形成 |
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| Outline of Final Research Achievements |
The efficacy of synaptic transmission changes depending on the pattern of neuronal activity. This synaptic plasticity has been regarded as a cellular basis of learning and memory. In this study, we have suggested that the amount of a subtype of AMPA-type glutamate receptors (AMPA receptors) on postsynaptic membrane is reduced together with dynamin during hippocampal long-term potentiation by experiments using total internal reflection fluorescence microscopy. In addition, we have developed a new method to visualize individual endocytosis of AMPA receptors.
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Report
(3 results)
Research Products
(8 results)
