| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Various immune cells were infiltrated in tumor tissue because tumor is inflammation and affect the malignant behavior of tumor cells. We investigated that interaction of tumor cells and neutrophils focusing on neutrophil extracellular traps (NETs) which is a new cell death and biological defense mechanism of neutrophils.
First, experimental system using bacteria to evaluate the NETs was established and reported. Then, by using the established NETs evaluation system, interaction of tumor cells and neutrophils was analyzed. As a results, it suggested the possibility that neutrophils infiltrating tumor tissue were promoted the invasion and metastasis of tumor via NETs formation.
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