Focus on neutrophil extracellular traps to control tumor cells
| Project/Area Number |
25890019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Teikyo University |
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Principal Investigator |
KAMOSHIDA Go 帝京大学, 医学部, 助手 (40707410)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | NETs / 好中球 / 細胞外 DNA / MMP / がん浸潤 / 細胞外DNA / TAM |
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| Outline of Final Research Achievements |
Various immune cells were infiltrated in tumor tissue because tumor is inflammation and affect the malignant behavior of tumor cells. We investigated that interaction of tumor cells and neutrophils focusing on neutrophil extracellular traps (NETs) which is a new cell death and biological defense mechanism of neutrophils.
First, experimental system using bacteria to evaluate the NETs was established and reported. Then, by using the established NETs evaluation system, interaction of tumor cells and neutrophils was analyzed. As a results, it suggested the possibility that neutrophils infiltrating tumor tissue were promoted the invasion and metastasis of tumor via NETs formation.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5).2014
Author(s)
Kamoshida, G., Ogawa, T., Oyanagi, J., Sato, H., Komiya, E., Higashi, S., Miyazaki, K., Tsuji, T.
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Journal Title
Clin. Exp. Metastasis
Volume: 31
Issue: 3
Pages: 285-291
DOI
Related Report
Peer Reviewed
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