Functional analysis of the novel metastasis-promoting factor Merm1
| Project/Area Number |
25890022
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
TAKEMOTO Ai 公益財団法人がん研究会, がん化学療法センター, 研究員 (20706494)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | がん転移 |
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| Outline of Final Research Achievements |
Merm1 is a metastasis-promoting factor isolated from in vivo screening. We performed the analysis of Merm1 to elucidate the mechanism of Merm1-regulated metastasis and to propose the new target for metastasis therapy. We found Merm1 MTase domain related to invasion ability of Merm1-expressing high metastatic cells. We searched Merm1-interactants and identified the conserved component of Merm1-holo complex and the ubiquitinylation enzymes which possibly regulate Merm1. And we observed that the some population of nuclear Merm1 localized in a nucleolus and Merm1 level and its MTase domain affected nucleolus morphology. Further analysis of the relationship between the interactants, the function in nucleolus and metastasis regulation by Merm1 is required.
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Report
(3 results)
Research Products
(6 results)
