Research Project
Grant-in-Aid for Research Activity Start-up
Merm1 is a metastasis-promoting factor isolated from in vivo screening. We performed the analysis of Merm1 to elucidate the mechanism of Merm1-regulated metastasis and to propose the new target for metastasis therapy. We found Merm1 MTase domain related to invasion ability of Merm1-expressing high metastatic cells. We searched Merm1-interactants and identified the conserved component of Merm1-holo complex and the ubiquitinylation enzymes which possibly regulate Merm1. And we observed that the some population of nuclear Merm1 localized in a nucleolus and Merm1 level and its MTase domain affected nucleolus morphology. Further analysis of the relationship between the interactants, the function in nucleolus and metastasis regulation by Merm1 is required.
All 2015 2014
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Presentation (4 results) Book (1 results)
Cancer Sci.
Volume: 105 Issue: 8 Pages: 983-988
10.1111/cas.12464
