Revealing NF-kB signal transduction system by experiment and simulation

• Project/Area Number: 25890025
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: System genome science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: INOUE Kentaro 独立行政法人理化学研究所, 統合生命医科学研究センター, 特別研究員 (80708529)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: NF-kB / シグナル伝達システム / シミュレーション / モデリング / NFkB / システム生物学 / シグナル伝達

Outline of Final Research Achievements

Transcription factor nuclear factor kappa B (NF-kB) is related to cell fate decision and various diseases. Mathematical model for NF-kB signal transduction system is useful to understand a regulatory mechanism of NF-kB activation. Previous models for NF-kB system can reproduce an oscillatory behavior for NF-kB activity. In this study, we constructed a model which reproduces not only the oscillatory behavior but also a switch-like response for NF-kB activity. This model is the largest model explaining a lot of experiments in NF-kB system.

Research Products

• [Presentation] BCRシグナリングによるNFkBの振動とスイッチライク応答のシステム解析 (2015)
  • Author(s): 井上健太郎, 篠原久明, 岡田眞里子
  • Organizer: 生命動態合同シンポジウム
  • Place of Presentation: 京都大学、京都府
  • Year and Date: 2015-03-15 – 2015-03-16
• [Presentation] System analysis for oscillation and switch-like response of NF-kappaB in B cell (2015)
  • Author(s): Kentaro Inoue, Hisaaki Shinohara, Mariko Okada-Hatakeyama
  • Organizer: The Third BMIRC International Symposium
  • Place of Presentation: のがみプレジデントホテル、福岡県
  • Year and Date: 2015-03-05 – 2015-03-06
• [Presentation] NF-kBシグナル伝達経路のモデリング (2015)
  • Author(s): 井上健太郎
  • Organizer: 第7回定量生物学の会
  • Place of Presentation: 九州大学、福岡県
  • Year and Date: 2015-01-11 – 2015-01-12
• [Presentation] 動力学モデルによる転写因子NFkB活性の振動およびデジタル応答の制御メカニズム解明 (2014)
  • Author(s): 井上健太郎, 篠原久明, 岡田眞里子
  • Organizer: 第３回生命医薬情報学連合大会
  • Place of Presentation: 仙台国際センター、宮城県
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] Kinetic modeling of NF-kappaB signaling pathway (2014)
  • Author(s): Kentaro Inoue, Hisaaki Shinohara, Marcelo Behar, Alexander Hoffmann, Mariko Okada-Hatakeyama
  • Organizer: 22nd Annual International Conference on Intelligent Systems for Molecular Biology (ISMB2014)
  • Place of Presentation: John B. Hynes Memorial Convention Center,Boston
  • Year and Date: 2014-07-13 – 2014-07-15
• [Presentation] Dynamic modeling of NF-kB signaling system in B cell (2014)
  • Author(s): 井上健太郎、篠原久明、岡田眞里子
  • Organizer: The Second BMIRC International Symposium
  • Place of Presentation: 飯塚研究開発センター, 福岡県
• [Presentation] Dynamic modeling of NF-kB signaling system in B cell (2013)
  • Author(s): 井上健太郎、篠原久明、岡田眞里子
  • Organizer: Genome Informatics Workshop (GIW2013)
  • Place of Presentation: National University of Singapore, Singapore
• [Presentation] Dynamic modeling for NF-kB signal transduction system (2013)
  • Author(s): 井上健太郎, 篠原久明, Marcelo Behar, Alexander Hoffmann, 岡田眞里子
  • Organizer: 第３６回分子生物学会年会
  • Place of Presentation: 神戸国際会議場、兵庫県
• [Presentation] System analysis for NF-kB signal transduction pathway (2013)
  • Author(s): 井上健太郎、篠原久明、岡田眞里子
  • Organizer: 第２回生命医薬情報学連合大会
  • Place of Presentation: タワーホール船橋、東京都
• [Remarks] 統合細胞システム研究チームホームページ
  • URL: http://csb.rcai.riken.jp/?lang=ja