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Comparative evolutionary analysis of endogenous viral elements among mammals

Research Project

Project/Area Number 25891023
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Evolutionary biology
Research InstitutionTokai University

Principal Investigator

NAKAGAWA So  東海大学, 医学部, 助教 (70510014)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords比較ゲノム / 内在性レトロウイルス / レトロトランスポゾン / ジャンクDNA / 分子進化 / バイオインフォマティクス / ゲノム進化 / データベース / 内在性ウイルス / ゲノムアノテーション / 胎盤
Outline of Final Research Achievements

Using 20 genomes from 19 mammalian species, we identified 736,765 nucleotide sequences that are possibly derived from viruses (called EVE). For each sequence, its locus, amino acid and nucleotide sequences, functional motifs, and similar endogenous/exogenous viral sequences were annotated. These results are publically available via a database (gEVE, http://geve.med.u-tokai.ac.jp).

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (14 results)

All 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Multiple invasions of an infectious retrovirus in cat genomes2015

    • Author(s)
      Shimode S, Nakagawa S, Miyazawa T
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 8164-8164

    • DOI

      10.1038/srep08164

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simian Retrovirus 4 Induces Lethal Acute Thrombocytopenia in Japanese Macaques.2015

    • Author(s)
      Yoshikawa Y, Okamoto M, Sakaguchi S, Nakagawa S, Miura T, Hirai H, Miyazawa T.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 7 Pages: 3965-3975

    • DOI

      10.1128/jvi.03611-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Construction of an infectious clone of simian foamy virus of Japanese macaque (SFVjm) and phylogenetic analyses of SFVjm isolates2014

    • Author(s)
      Yoshikawa R, Nakagawa S, Okamoto M, Miyazawa T.
    • Journal Title

      Gene

      Volume: 548 Issue: 1 Pages: 149-154

    • DOI

      10.1016/j.gene.2014.07.025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of koala retrovirus isolates.2014

    • Author(s)
      Shimode S, Nakagawa S, Yoshikawa R, Shojima T, Miyazawa T.
    • Journal Title

      FEBS Letters

      Volume: 588 Issue: 1 Pages: 41-46

    • DOI

      10.1016/j.febslet.2013.10.046

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 哺乳類のゲノムに内在化するウイルス由来の配列の比較解析2014

    • Author(s)
      中川草
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] RNA-seq analysis of endogenous retroviral elements in bovine conceptuses during the period of placentation2014

    • Author(s)
      NAKAGAWA, So
    • Organizer
      The American Society of Human Genetics
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-10-17 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 次世代シーケンサを用いたウシ胎盤形成に関与する内在性ウイルス由来の遺伝子の分子進化解析2014

    • Author(s)
      中川草
    • Organizer
      第3回生命医薬情報学連合大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-10-02 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノムに内在化したウイルス由来の配列の比較ゲノム解析2014

    • Author(s)
      中川草
    • Organizer
      日本遺伝学会
    • Place of Presentation
      長浜
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 哺乳類のゲノムに内在化したウイルス由来の配列データベース2014

    • Author(s)
      中川草
    • Organizer
      日本進化学会
    • Place of Presentation
      高槻
    • Year and Date
      2014-08-21 – 2014-08-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] TRANSCRIPTOME ANALYSIS OF ERV-DERIVED GENES IN BOVINE CONCEPTUSES DURING THE PERIOD OF PLACENTATION2014

    • Author(s)
      NAKAGAWA, So
    • Organizer
      Workshop on Endogenous Retroviruses
    • Place of Presentation
      West Virginia, USA
    • Year and Date
      2014-08-07 – 2014-08-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内在性ウイルスのデータベース作成に向けて2014

    • Author(s)
      中川草
    • Organizer
      日本レトロウイルス研究会夏期セミナー
    • Place of Presentation
      熱海
    • Year and Date
      2014-07-03 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Remarks] Biomedical Informatics Laboratory

    • URL

      http://bmi.med.u-tokai.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東海大学マイクロ・ナノ研究開発センター

    • URL

      http://www.mnc.u-tokai.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] So Nakagawa Website

    • URL

      https://sites.google.com/site/sonakagawa/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-09-12   Modified: 2019-07-29  

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