Development of analytical method for the organohalogen metabolites elucidation of metavolic capacities and risk assessment in the pet cat
Project/Area Number |
25892001
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Veterinary medical science
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Research Institution | Hokkaido University |
Principal Investigator |
MIZUKAWA Hazuki 北海道大学, (連合)獣医学研究科, 助教 (60612661)
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Research Collaborator |
ISHIZUKA Mayumi 北海道大学, 大学院獣医学研究科・毒性学教室, 教授
IKENAKA Yoshinori 北海道大学, 大学院獣医学研究科・毒性学教室, 准教授
NAKAYAMA Shouta 北海道大学, 大学院獣医学研究科・毒性学教室, 助教
TAKIGUCHI Mitsuyoshi 北海道大学, 大学院獣医学研究科・内科学教室, 教授
NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センター化学汚染・毒性解析部門, 准教授
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Project Period (FY) |
2013-08-30 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | ネコ / 有機ハロゲン化合物 / 血清 / 環境分析 / 水酸化代謝物 / ペット / 第I相反応 / 第II相反応 / 代謝物 / PBDEs / 甲状腺機能亢進症 / PCBs |
Outline of Final Research Achievements |
This study was develop the analyzing method for hydroxylated polybrominated diphenyl ethers (OH-PBDEs) and the glucuronidation compounds of OH-PCBs using liquid chromatography tandem mass spectrometry (LC-MS/MS). Moreover, it was measured the glucuronidation activities using the liver microsomes of the cats. I also attempted the evaluation of metabolic capacities of PCBs and PBDEs in the cats.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Identification of inter-specific differences in phase II reactions: Determination of metabolites in the urine of 16 mammalian species exposed to environmental pyrene.2015
Author(s)
Saengtienchai A, Ikenaka Y, Nakayama SMM, Mizukawa H, Kakehi M, Bortey-Sam N, Darwish W, Tsubota T, Terasaki M, Poapolathep A, Ishizuka M
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Journal Title
Environmental Toxicology and Chemistry
Volume: 33
Issue: 9
Pages: 2062-2069
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Contamination status and biotransformation of organohalogen compounds in cats and dogs,2014
Author(s)
Hazuki Mizukawa, Kei Nomiyama, Susumu Nakatsu, Akira Kubota, Hisato Iwata, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka
Organizer
12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
Place of Presentation
Conference Hall of the Kyoto International Foundation, Kyoto, Japan
Year and Date
2014-09-24 – 2014-09-28
Related Report
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[Presentation] Mammalian interspecies differences in xenobiotic phase II reaction2014
Author(s)
Yoshinori Ikenaka, Saengtienchai Aksorn, Mayu Kakehi, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
Organizer
12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
Place of Presentation
Conference Hall of the Kyoto International Foundation, Kyoto, Japan
Year and Date
2014-09-24 – 2014-09-28
Related Report
Invited
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[Presentation] Species differences of UDP-glucuronosyltransferases (UGTs) in Carnivores2014
Author(s)
Mayu Kakehi, Yoshinori Ikenaka, Shouta MM Nakayama, Hazuki Mizukawa,Kensuke P Watanabe, Kentaro Sakamoto, Akihiko Wada, Kaoru Hattori,Shinsuke Tanabe, Kei Nomiyama, Mayumi Ishizuk
Organizer
12th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
Place of Presentation
Conference Hall of the Kyoto International Foundation, Kyoto, Japan
Year and Date
2014-09-24 – 2014-09-28
Related Report
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