| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In 2013, we demonstrated that brain magnetic resonance imaging and behavioral tests revealed significant reduction in gray matter in the hippocampus and increase in depressive symptoms respectively in HF rats compared with sham rats. In 2014, brain histological analysis reviealed significant decrease in neurogenesis and neurite outgrowth and increase in the number of astrocytes in the hippocampus in HF rats compared with sham rats. Gray matter in the hippocampus was significantly correlated with depressive symptoms in HF rats. Therefore, the results of this study demonstrated for the first time that the structural abnormality of the hippocampus is associated with depressive symptoms in HF and has been accepted in the peer-reviewd journal, NeuroImage.
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