Structural brain abnormality in heart failure rats

• Project/Area Number: 25893010
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: SUZUKI Hideaki 東北大学, 大学病院, 助教 (20705462)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 循環器内科 / 心不全 / 海馬 / 脳 / うつ / MRI / 循環器 / 心臓 / ラット

Outline of Final Research Achievements

In 2013, we demonstrated that brain magnetic resonance imaging and behavioral tests revealed significant reduction in gray matter in the hippocampus and increase in depressive symptoms respectively in HF rats compared with sham rats. In 2014, brain histological analysis reviealed significant decrease in neurogenesis and neurite outgrowth and increase in the number of astrocytes in the hippocampus in HF rats compared with sham rats. Gray matter in the hippocampus was significantly correlated with depressive symptoms in HF rats. Therefore, the results of this study demonstrated for the first time that the structural abnormality of the hippocampus is associated with depressive symptoms in HF and has been accepted in the peer-reviewd journal, NeuroImage.

Research Products

• [Journal Article] Right-sided infective endocarditis as a potentially fatal complication in patients with long-term refractory severe bradyarrhythmia after cervical spinal cord injury: A case report. (2015)
  • Author(s): Miura N, Suzuki H, Maesawa S, Koakutsu T, Matsumoto Y, Fukuda K, Kagaya Y, Kushimoto S, Shimokawa H.
  • Journal Title: J Arrhythmia. Volume: in press Issue: 4 Pages: 232-234
  • DOI: 10.1016/j.joa.2014.11.002
  • Peer Reviewed / Open Access
• [Journal Article] Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats. (2015)
  • Author(s): Suzuki H, Sumiyoshi A, Matsumoto Y, Duffy BA, Yoshikawa T, Lythgoe MF, Yanai K, Taki Y, Kawashima R, Shimokawa H.
  • Journal Title: Neuroimage. Volume: 105 Pages: 84-92
  • DOI: 10.1016/j.neuroimage.2014.10.040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Burn-associated dilated cardiomyopathy evaluated by cardiac PET and SPECT: Report of a case. (2014)
  • Author(s): Fukui R, Suzuki H, Miyagawa N, Endo T, Kaneta T, Sugimura K, Matsumoto Y, Takahashi S, Kagaya Y, Kushimoto S, Shimokawa H.
  • Journal Title: J Cariol Cases. Volume: 10 Issue: 5 Pages: 180-183
  • DOI: 10.1016/j.jccase.2014.07.005
  • Peer Reviewed
• [Journal Article] Cerebral Blood Flow in Takotsubo Syndrome: Is it Specific for the Disease? (2014)
  • Author(s): Suzuki H, Matsumoto Y, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 78 Issue: 3 Pages: 776
  • DOI: 10.1253/circj.CJ-13-1570
  • NAID: 130003391013
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Evidence for Brain Activation in Patients With Takotsubo Cardiomyopathy (2014)
  • Author(s): Suzuki H, Matsumoto Y, Kaneta T, Sugimura K, Takahashi J, Fukumoto Y, Takahashi S, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 78 Issue: 1 Pages: 256-258
  • DOI: 10.1253/circj.CJ-13-1276
  • NAID: 130003382194
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Voxel-based morphometry and histological analysis for evaluating hippocampal damage in a rat model of cardiopulmonary resuscitation. (2013)
  • Author(s): Suzuki H, Sumiyoshi A, Taki Y, Matsumoto Y, Fukumoto Y, Kawashima R, Shimokawa H.
  • Journal Title: Neuroimage. Volume: 77 Pages: 215-221
  • DOI: 10.1016/j.neuroimage.2013.03.042
  • Peer Reviewed
• [Journal Article] Different brain activation under left and right ventricular stimulation: an fMRI study in anesthetized rats. (2013)
  • Author(s): Suzuki H, Sumiyoshi A, Kawashima R, Shimokawa H.
  • Journal Title: PLoS One. Volume: 8 Issue: 2 Pages: e56990-e56990
  • DOI: 10.1371/journal.pone.0056990
  • Peer Reviewed
• [Presentation] 心室頻拍を繰り返した左室緻密化障害(LVNC)による重症心不全の一例 (2014)
  • Author(s): 星陽介, 鈴木秀明, 青木竜男, 羽尾清貴, 杉村宏一郎, 高橋潤, 佐藤哲哉, 藤田基生, 加賀谷豊, 久志本成樹, 下川宏明
  • Organizer: 第159回日本循環器学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2014-12-06
• [Presentation] シャント感染に感染性心内膜炎を合併し死亡した一例 (2014)
  • Author(s): 田中祥朗, 鈴木秀明, 山内彩記子, 加賀谷豊, 久志本成樹, 下川宏明
  • Organizer: 第159回日本循環器学会東北地方会
  • Place of Presentation: 仙台
  • Year and Date: 2014-12-06
• [Presentation] Evidence for Activation of Cerebral Autonomic Center in Response to Cardiac Electrical Stimulation in Humans -A New Finding of Cardio-Cerebral Connection- (2014)
  • Author(s): Suzuki H, Satoh K, Tatebe S, Matsumoto Y, Kondo M, Nakano M, Fukuda K, Watanuki S, Hiraoka K, Tashiro M, Shimokawa H
  • Organizer: AHA 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 慢性心不全における脳の構造・機能に 関する臨床研究 (B-HeFT) (2014)
  • Author(s): 鈴木秀明, 松本泰治, 古川勝敏, 瀧靖之, 荒井啓行, 下川宏明
  • Organizer: 第25回日本老年医学会東北地方会
  • Place of Presentation: 福島
  • Year and Date: 2014-10-11 – 2014-10-12
  • Invited
• [Presentation] 広範囲熱傷患者に発症した拡張型心筋症の一例 (2014)
  • Author(s): 福井玲矛, 鈴木秀明, 宮川乃理子, 遠藤智之, 金田朋洋, 杉村宏一郎, 松本泰治, 加賀谷豊, 久志本成樹, 下川宏明
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 右心系心内膜炎を合併し、ペースメーカー留置を行わなかった頚髄損傷による心停止の一例 (2014)
  • Author(s): 三浦直晃, 鈴木秀明, 前澤翔太, 小圷知明, 福田浩二, 加賀谷豊, 久志本成樹, 下川宏明
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] プランマー病に合併したたこつぼ型心筋症の一例 (2014)
  • Author(s): 三浦隆介, 鈴木秀明, 松本泰治, 尾崎泰, 羽尾清貴, 円谷隆治, 高橋潤, 伊藤健太, 伊藤貞嘉, 加賀谷豊, 久志本成樹, 下川宏明
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Decreased cerebral blood flow and BDNF levels are associated with depression and memory impairment in patients with heart failure -Brain Assessment and Investigation in Heart Failure Trial (B-HeFT)- (2014)
  • Author(s): Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Fukumoto Y, Kawashima R, Taki Y, Shimokawa H
  • Organizer: ESC Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03