Organella recycle system by autophagy in epidermis

• Project/Area Number: 25893011
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Toshiya 東北大学, 大学病院, 医員 (30712195)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: オートファジー / 皮膚疾患 / 皮膚

Outline of Final Research Achievements

We confirmed the expression of LC3B, which is key molecule in autophagy, to epidermis and skin adnexa. In addition, in psoriasis and atopic dermatitis, expression of LC3B in the epidermis granular layer was more strongly seen. Moreover, by the experiment using the normal human epidermal keratinocyte, TLR9 ligand stimulation enhanced expression of LC3B.
These results suggested association between autophagy and synthesis of many molecules, and that bacterial infection may induce autophagy and following various material composition in the skin, but did not come to clarify the mechanism.