| Project/Area Number |
25893020
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontics/Pediatric dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-08-30 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | Scleraxis / 歯根膜細胞 / メカニカルストレス |
|---|
| Outline of Final Research Achievements |
Scleraxis (Scx), a transcription factor, is predominantly expressed in tendons and ligaments including the periodontal ligament (PDL). In this study, we investigated Scx expression in the PDL during experimental tooth movement. Scx expression was significantly up-regulated on the tension side of the PDL, whereas it was down-regulated on the compression side. Up-regulation of Scx was followed by activation of the transforming growth factor-beta (TGF-β) signaling as evidenced by detection of increased active-TGF-β1 and the significant increase of phospho-Smad3 positive PDL fibroblasts on the tension side. TGF-β2 positively regulated the expression of Scx in cultured PDL fibroblasts. These findings suggest that tensile force responsive up-regulation of Scx in the PDL is mediated through activation of the TGF-β/Smad3 signaling pathway.
|
