A clinical study of boron neutron capture therapy for head and neck cancer

• Project/Area Number: 25893023
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: OHNISHI Kayoko 筑波大学, 医学医療系, 講師 (60529832)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 硼素中性子補足療法 / 再発頭頸部癌 / 再照射 / 頭頸部癌

Outline of Final Research Achievements

Boron neutron capture therapy (BNCT) delivers tumor cell-selective, high linear energy transfer (LET) radiation without serious damage to surrounding normal tissue. We are now preparing to start BNCT usign accelerator-based neutron sources. In this study, BNCT showed good local control with acceptable toxicities in patients with recurrent head and neck cancer who had a previous history of definitive radiotherapy. BNCT could be an effective treatment option for recurrent head and neck cancer.

Research Products

• [Journal Article] [Liver cancer: progress in diagnosis and treatments. Topics: VI. Progress in treatments of liver cancer; 7. Radiotherapy of liver cancer]. (2014)
  • Author(s): Fukumitsu N, Okumura T, Ishikawa H, Ohnishi K, Mizumoto M, Numajiri H, Tsuboi K, Sakurai H
  • Journal Title: Nihon Naika Gakkai zasshi Volume: 103 Pages: 116-122
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for a patient with a giant thymic carcinoid tumor and severe superior vena cava syndrome. (2014)
  • Author(s): Sugawara K, Mizumoto M, Numajiri H, Ohno T, Ohnishi K, Ishikawa H, Okumura T, Sakurai H.
  • Journal Title: Rare Tumors Volume: 13 Issue: 2 Pages: 5177-5177
  • DOI: 10.4081/rt.2014.5177
  • Peer Reviewed / Open Access
• [Journal Article] Association between pretreatment retention rate of indocyanine green 15min after administration and life prognosis in patients with HCC treated by proton beam therapy. (2014)
  • Author(s): Mizumoto M, Oshiro Y, Okumura T, Fukuda K, Fukumitsu N, Abei M, et al.
  • Journal Title: Radiother Oncol Volume: 113 Issue: 1 Pages: 54-59
  • DOI: 10.1016/j.radonc.2014.08.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dose distribution resulting from changes in aeration of nasal cavity or paranasal sinus cancer in the proton therapy. (2014)
  • Author(s): Fukumitsu N, Ishikawa H, Ohnishi K, Terunuma T, Mizumoto M, Numajiri H, Aihara T, Okumura T, Tsuboi K, Sakae T, Sakurai H.
  • Journal Title: Radiother Oncol. Volume: 113 Issue: 1 Pages: 72-76
  • DOI: 10.1016/j.radonc.2014.08.024
  • NAID: 120007136377
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 筑波大学におけるBNCT臨床研究再開計画について (2014)
  • Author(s): 田中圭一、粟飯原輝人、熊田博明、奥村敏之、石川仁、福光延吉、大西かよ子、水本斉志、室伏景子、沼尻晴子、松村明、鈴木実、櫻井英幸
  • Organizer: 日本放射線腫瘍学会第27回大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] 当院における下咽頭扁平上皮癌に対する放射線治療成績 (2014)
  • Author(s): 大西かよ子、粟飯原輝人、石川仁、水本斉志、室伏景子、沼尻晴子、斎藤高、福光延吉、坪井康次、奥村敏之、櫻井英幸
  • Organizer: 日本放射線腫瘍学会第27回大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] 進行肺癌に対する放射線治療の可能性②：粒子線併用放射線治療 (2014)
  • Author(s): 石川仁、大西かよ子、大城佳子、水本斉志、奥村敏之、櫻井英幸
  • Organizer: 日本肺癌学会・日本臨床腫瘍学会/合同シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2014-12-11
• [Presentation] 筑波大学における頭頸部BNCTの経過報告 (2014)
  • Author(s): 大西かよ子
  • Organizer: 2014年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 京都大学原子炉実験所事務棟大会議室
  • Year and Date: 2014-09-29 – 2014-09-30
• [Presentation] 筑波大学頭頸部BNCTの経過報告 (2014)
  • Author(s): 大西かよ子、粟飯原輝人、石川仁、福光延吉、奥村敏之、水本斉志、松本孔貴、田中圭一、長野拓也、櫻井英幸
  • Organizer: 平成26年度京都大学原子炉実験所専門研究会
  • Place of Presentation: 京都大学原子炉実験所
  • Year and Date: 2014-09-29 – 2014-09-30
• [Presentation] 食道癌の化学放射線療法と陽子線治療の役割 (2014)
  • Author(s): 石川仁、奥村敏之、水本斉志、大西かよ子、菅原香織、牧島弘和、大野豊然貴、森脇俊和、兵頭一之介、久倉勝治、田村孝史、寺島秀人、大河内信弘、橋本孝之、櫻井英幸
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] Four Cases of Recurrent Head and Neck Cancer Treated with Boron Neutron Capture Therapy at University of Tsukuba (2014)
  • Author(s): 大西かよ子
  • Organizer: 第11回日本中性子補足療法学会学術大会
  • Place of Presentation: 大阪大学コンベンションセンター
  • Year and Date: 2014-07-05 – 2014-07-06
• [Presentation] 臨床研究再開に伴い硼素中性子補足療法を施行した頭頸部癌４例 (2014)
  • Author(s): 大西かよ子、粟飯原輝人、石川仁、福光延吉、水本斉志、室伏景子、沼尻晴子、中井啓、長谷川正午、山本哲哉、和田哲郎、奥村敏之、松村明、櫻井英幸
  • Organizer: 第11回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-05 – 2014-07-06
• [Presentation] Overview of the re-initiation of BNCT clinical studies at the University of Tsukuba (2014)
  • Author(s): 粟飯原輝人
  • Organizer: 16th International Congress on Neutron Capture Therapy
  • Place of Presentation: ヘルシンキ
  • Year and Date: 2014-06-14 – 2014-06-19
• [Presentation] 筑波大学におけるBNCT臨床研究再開計画について (2014)
  • Author(s): 田中圭一、粟飯原輝人、熊田博明、福光延吉、奥村敏之、石川仁、大西かよ子、水本斉志、沼尻晴子、和田哲郎、原晃、硲田猛真、鈴木実、櫻井英幸
  • Organizer: 第38回日本頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] 中・下咽頭癌の放射線治療成績 (2014)
  • Author(s): 大西かよ子、粟飯原輝人、石川仁、和田哲郎、水本斉志、沼尻晴子、福光延吉、奥村敏之、原晃、櫻井英幸
  • Organizer: 第38回日本頭頸部癌学会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] 陽子線治療を行った転移性肝癌の生存率についての研究 (2014)
  • Author(s): 福光延吉、奥村敏之、沼尻晴子、大西かよ子、水本斉志、粟飯原輝人、石川仁、坪井康次、櫻井英幸
  • Organizer: 第50回日本肝癌研究会
  • Place of Presentation: 京都
  • Year and Date: 2014-06-05 – 2014-06-06
• [Presentation] Boron-neutron capture therapy for newly diagnosed head and neck cancer in initial treatment (2013)
  • Author(s): Aihara T, Morita N, Kamitani N, Kumada H, Fukumitsu N, Sakurai Y, Ohnishi K, Hiratsuka J, Sakurai H
  • Organizer: 7th Young Researchers BNCT Meeting
  • Place of Presentation: Guranada, Spain
  • Year and Date: 2013-09-22 – 2013-09-26
• [Presentation] 筑波大学のＢＮＣＴ臨床研究再開計画について (2013)
  • Author(s): 粟飯原輝人 山本哲哉 熊田博明 中井啓 石川仁 福光延吉 奥村敏之 大西かよ子 水本斉志 沼尻晴子 大野豊然貴 瀧澤大地 菅原香織 松村明 櫻井英幸
  • Organizer: 第10回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2013-09-07 – 2013-09-08