Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations
| Project/Area Number |
25893026
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アルドステロン産生腺腫 / KCNJ5遺伝子変異 / 原発性アルドステロン症 |
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| Outline of Final Research Achievements |
Somatic mutations of the potassium channel KCNJ5 gene have been recently identified in patients with adrenal aldosterone-producing adenomas (APAs). In the present study,we identified 76% of KCNJ5 mutations in APAs. They were younger and showed higher plasma aldosterone levels, lower potassium levels and higher diastolic blood pressure(p<0.05,p<0.05, p<0.01 and p<0.05, respectively). Reflecting these phenotypes, they had higher CYP11B2 mRNA levels. However, in contrast to APAs in Western countries, Japanese APAs with mutations showed lower CYP11B1, CYP17A1, and CYP11A1 mRNA levelsp<0.01,p<0.02, p<0.01 and p<0.05, respectively). These findings demonstrated that Japanese APAs may have distinct features including a higher prevalence of KCNJ5 mutations and characteristics similar to the zona glomerulosa.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol2014
Author(s)
Nakajima Y, Okamura T, Gohko T, Satoh T, Hashimoto K, Shibusawa N, Ozawa A, Ishii S, Tomaru T, Horiguchi K, Okada S, Takata D, Rokutanda N, Horiguchi J, Tsushima Y, Oyama T, Takeyoshi I, Yamada M.
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Journal Title
Endocrine Journal
Volume: 61(8)
Pages: 825-832
Related Report
Peer Reviewed / Open Access
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