• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations

Research Project

Project/Area Number 25893026
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionGunma University

Principal Investigator

NAKAJIMA Yasuyo  群馬大学, 医学部附属病院, 助教 (70707017)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアルドステロン産生腺腫 / KCNJ5遺伝子変異 / 原発性アルドステロン症
Outline of Final Research Achievements

Somatic mutations of the potassium channel KCNJ5 gene have been recently identified in patients with adrenal aldosterone-producing adenomas (APAs). In the present study,we identified 76% of KCNJ5 mutations in APAs. They were younger and showed higher plasma aldosterone levels, lower potassium levels and higher diastolic blood pressure(p<0.05,p<0.05, p<0.01 and p<0.05, respectively). Reflecting these phenotypes, they had higher CYP11B2 mRNA levels. However, in contrast to APAs in Western countries, Japanese APAs with mutations showed lower CYP11B1, CYP17A1, and CYP11A1 mRNA levelsp<0.01,p<0.02, p<0.01 and p<0.05, respectively). These findings demonstrated that Japanese APAs may have distinct features including a higher prevalence of KCNJ5 mutations and characteristics similar to the zona glomerulosa.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (11 results)

All 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results) Book (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol2014

    • Author(s)
      Nakajima Y, Okamura T, Gohko T, Satoh T, Hashimoto K, Shibusawa N, Ozawa A, Ishii S, Tomaru T, Horiguchi K, Okada S, Takata D, Rokutanda N, Horiguchi J, Tsushima Y, Oyama T, Takeyoshi I, Yamada M.
    • Journal Title

      Endocrine Journal

      Volume: 61(8) Pages: 825-832

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 各種コルチゾール産生腺腫におけるPRKACA遺伝子変異の検討2015

    • Author(s)
      中島康代、岡村孝志、堀口和彦、松本俊一、登丸琢也、石井角保、小澤厚志、渋沢信行、橋本貢士、佐藤哲郎、山田正信
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京
    • Year and Date
      2015-04-23 – 2015-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] KCNJ5変異と原発性アルドステロン症2014

    • Author(s)
      中島康代
    • Organizer
      第24回臨床内分泌UPDATE
    • Place of Presentation
      大宮ソニックシティー
    • Year and Date
      2014-11-28 – 2014-11-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] アルドステロン産生腺腫におけるKCNJ5遺伝子変異とステロイド合成酵素発現の特徴2014

    • Author(s)
      岡村孝志、中島康代、堀口和彦、松本俊一、登丸琢也、石井角保、小澤厚志、渋沢信行、橋本貢士、佐藤哲郎、山田正信
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡国際 会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Book] ホルモンと臨床 遺伝子変異陽性のアルドステロン産生腺腫の意義2015

    • Author(s)
      中島康代、山田正信
    • Total Pages
      6
    • Publisher
      医学の世界者
    • Related Report
      2014 Annual Research Report
  • [Book] Fluid Management Renaissance 原発性アルドステロン症の新たな知見2015

    • Author(s)
      中島康代、山田正信
    • Total Pages
      10
    • Publisher
      メディカルレビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] 臨床画像 原発性アルドステロン症(KCNJ5遺伝子異常)2015

    • Author(s)
      中島康代
    • Total Pages
      2
    • Publisher
      メディカルビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] ホルモンと臨床:KCNJ5遺伝子と副腎腫瘍2013

    • Author(s)
      中島 康代、山田 正信
    • Total Pages
      7
    • Publisher
      医学の世界社
    • Related Report
      2013 Annual Research Report
  • [Book] 血圧:原発性アルドステロン症における新たな遺伝子異常2013

    • Author(s)
      中島 康代、山田 正信
    • Total Pages
      7
    • Publisher
      先端医学社
    • Related Report
      2013 Annual Research Report
  • [Book] カレントテラピー:KCNJ5変異の病態生理学的意義2013

    • Author(s)
      中島 康代、山田 正信
    • Total Pages
      6
    • Publisher
      ライフメディコム
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] PRKACA遺伝子を使用したクッシング症候群を呈する コルチゾール産生腫瘍の検査方法2014

    • Inventor(s)
      山田 正信、中島 康代, 堀口 和彦、 岡村 孝志
    • Industrial Property Rights Holder
      山田 正信、中島 康代, 堀口 和彦、 岡村 孝志
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-132908
    • Filing Date
      2014-06-27
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-09-12   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi