Molecular mechanisms of Th9 cell-mediated chronic inflammation
Project/Area Number |
25893033
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Chiba University |
Principal Investigator |
YAGI Ryoji 千葉大学, 医学(系)研究科(研究院), 特任准教授 (20392152)
|
Project Period (FY) |
2013-08-30 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 免疫学 / アレルギー・ぜんそく / Th9 / ヘルパーT細胞 / 遺伝子発現制御 / サイトカイン / IL-9 / Th9細胞 / アレルギー / 転写因子 / 炎症 / 遷延化 / T細胞 / 免疫 |
Outline of Final Research Achievements |
Naive CD4 T cells can differentiate into several T helper (Th) cell subsets, Th1, Th2, Th17, regulatory T cells and follicular T cells. Recently Th9 cells have been added into Th cell subsets. Th9 cells are known to induce proliferation of mast cells and secretion of mucus from goblet cells and also to be involved in allergic diseases. IL-4 and TGFβ are required for Th9 cell differentiation from naive CD4 T cells in vitro. However, the molecular mechanism of Th9 cell differentiation and the function of Th9 cells in vivo are not understood yet. To study these questions, we focused on a responsible gene which we found previously and we established an in vivo model to investigate role of the gene on Th9 cell differentiation.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.2014
Author(s)
Yagi, R., Zhong, C., Northrup, D. L., Yu, F., Bouladoux, N., Spencer, S., Hu, G., Barron, L., Sharma, S., Nakayama, T., Belkaid, Y., Zhao, K., and Zhu, J.
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Journal Title
Immunity
Volume: 40
Issue: 3
Pages: 378-388
DOI
Related Report
Peer Reviewed
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[Journal Article] Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.2013
Author(s)
Hosokawa H, Tanaka T, Kato M, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Sakikawa I, Morita A, Nagira M, Suzuki Y, Nakayama T.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 110(46)
Issue: 46
Pages: 18626-18631
DOI
Related Report
Peer Reviewed
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