| Project/Area Number |
25893034
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory surgery
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| Research Institution | Chiba University |
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Principal Investigator |
YUN Takamasa 千葉大学, 医学部附属病院, 医員 (80710491)
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| Research Collaborator |
YOSHINO Ichiro 千葉大学, 大学院医学研究院, 教授 (40281547)
YOSHIDA Shigetoshi 千葉大学, 大学院医学研究院, 准教授 (90334200)
MIZOBUCHI Teruaki 日産厚生会玉川病院, 呼吸器外科, 副部長 (50569861)
IWATA Takekazu 千葉大学, 医学部附属病院, 講師 (30586681)
SUZUKI Hidemi 千葉大学, 大学院医学研究院, 助教 (60422226)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 代償性肺成長 / 肺 / 再生 / 画像 / 遺伝子 / マウス / 移植 |
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| Outline of Final Research Achievements |
We recently developed the way of evaluation for lung weight using radiologic analysis in post-pulmonary resection adult human. In this study, we serially evaluated morhologic, radiologic and genomic status during CLG in pneumonectomized mice.After left pneumonectomy, the right lung progressively enlarged both in volume and weight during observation period. Estimated weight also increased associated with the real volume. Among the lobes, the cardiac lobe markedly increased in size. The alveolar density was always lower in pneumonectomized mice than in sham controls. Microarray analysis revealed that multiple genes related to proliferation (but not specific alveolar development) were initially upregulated and then returned to normal after 30 day. The morphologic and genomic changes were more evident in the cardiac lobe than in the upper lobe. During CLG, morphologic, radiologic and genomic changes were related to each other in pneumonectomized mice.
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