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The analysis of ASK1 pathway in brown adipocytes

Research Project

Project/Area Number 25893036
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

HATTORI Kazuki  東京大学, 薬学研究科(研究院), 特任助教 (40708575)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords褐色脂肪 / ASK1 / Ucp1 / 熱産生 / 脂肪分化
Outline of Final Research Achievements

Brown adipose tissue is in the spotlight as a therapeutic target for some metabolic diseases. We revealed that the expression levels of specific subset of genes, which are known to be involved in thermogenesis, were suppressed in ASK1-deficient brown adipose tissue by DNA microarray analysis. Further analysis using primary culture of brown adipocytes elucidated that PKA-ASK1-p38 pathway is activated during the course of differentiation, which leads to gene induction, including Ucp1, and induces maturation of brown adipocytes.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (11 results)

All 2014 2013

All Presentation (11 results)

  • [Presentation] 新規ケミカルプルダウン法を用いた褐色脂肪細胞におけるASK1複合体構成因子の同定2014

    • Author(s)
      曽我真弓、服部一輝、一條秀憲
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 褐色脂肪細胞の成熟化におけるASK1の機能解析2014

    • Author(s)
      服部一輝、一條秀憲
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規ケミカルプルダウン法を用いた褐色脂肪細胞におけるASK1複合体構成因子の同定2014

    • Author(s)
      曽我真弓、服部一輝、一條秀憲
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ストレス応答性キナーゼASK1の脂肪組織における新規機能解析2014

    • Author(s)
      古谷昌太朗、服部一輝、一條秀憲
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cold stress induces cell death through the activation of ASK1-p38 pathway2014

    • Author(s)
      Hattori, K., Ishikawa, H., Naguro, I., Ichijo, H.
    • Organizer
      Thiol-Based Redox Regulation & Signaling(Gordon Research Conference)
    • Place of Presentation
      Girona, Spain
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ASK1による褐色脂肪細胞の分化制御2014

    • Author(s)
      古谷昌太朗、服部一輝、一條秀憲
    • Organizer
      第23回日本Cell Death学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analog-sensitive kinaseを用いたプルダウン法による新規ASK1複合体構成因子の同定2014

    • Author(s)
      曽我真弓、服部一輝、丸山 剛、一條秀憲
    • Organizer
      第14回東京大学生命科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ASK1 regulates brown adipocyte differentiation2014

    • Author(s)
      Kazuki Hattori, Isao Naguro and Hidenori Ichijo
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] 褐色脂肪細胞の分化におけるASK1の新規機能解析2013

    • Author(s)
      服部一輝、古谷昌太朗、名黒功、一條秀憲
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The analysis of ASK1 function in blood glucose regulation2013

    • Author(s)
      Furutani, S., Hattori, K., Ichijo, H
    • Organizer
      The 8th Japan-Korea conference on cellular signalling for young scientists
    • Place of Presentation
      九州大学(福岡県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ストレス応答性キナーゼASK1の血糖値制御に関わる機能解析2013

    • Author(s)
      古谷昌太朗、服部一輝、一條秀憲
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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