Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
Brown adipose tissue is in the spotlight as a therapeutic target for some metabolic diseases. We revealed that the expression levels of specific subset of genes, which are known to be involved in thermogenesis, were suppressed in ASK1-deficient brown adipose tissue by DNA microarray analysis. Further analysis using primary culture of brown adipocytes elucidated that PKA-ASK1-p38 pathway is activated during the course of differentiation, which leads to gene induction, including Ucp1, and induces maturation of brown adipocytes.
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