| Project/Area Number |
25893043
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
HARA Hironori
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 心筋再生 / 成体心筋細胞 / Fucciシステム / 細胞周期 / Hippo経路 / YAP / 創薬 / 心筋細胞 / 分裂能 |
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| Outline of Final Research Achievements |
Although a consensus has emerged that cardiomyocytes themselves are the most prominent source of ongoing cardiomyocyte renewal in the adult mammalian heart, those cardiomyocytes having the potential to proliferate for regeneration have not been well characterized. To visualize and isolate live mitotic cardiomyocytes, we generated useful in vitro and in vivo systems allowing investigation of cell cycle status in cardiomyocytes by use of the Fucci technology. In addition, we performed high-throughput screening for Yes-associated protein (YAP)-activating drugs, which could modulate Hippo signaling pathway to promote cardiomyocyte proliferation and survival. These need to be verified in animal models of cardiogenesis and heart failure, but would provide new insights on adult heart regeneration strategies by enhancing cardiomyocyte proliferation, in the near future.
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