Gq stress induced right heart remodeling and its modulation by cGMP

• Project/Area Number: 25893044
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: TAKIMOTO Eiki 東京大学, 医学部附属病院, 准教授 (20709513)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 心不全 / 心肥大 / Ｇｑシグナル / ｃＧＭＰ / 遺伝子 / Ｇｑストレス / アポトーシス / cGMP / RNAシーケンス / 右心不全 / 左心不全 / 血管新生

Outline of Final Research Achievements

Right heart hypertrophy/failure is clinically important, but its molecular mechanisms remain largely elusive. We performed comprehensive transcriptome analysis of right heart myocytes and left heart myocytes exposed to Gq stress, and found intriguing differences between right and left cardiac myocytes.