Functional analysis of human LMIR3/CD300F
Project/Area Number |
25893050
|
Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Collagenous pathology/Allergology
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Research Institution | The University of Tokyo |
Principal Investigator |
IZAWA Kumi 東京大学, 医科学研究所, 助教 (80708313)
|
Project Period (FY) |
2013-08-30 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | マスト細胞 / アレルギー / IgE / スフィンゴミエリン / セラミド / 免疫学 |
Outline of Final Research Achievements |
Leukocyte mono-immunoglobulin-like receptor (LMIR) belongs to a paired activating and inhibitory receptor family. Mouse LMIR3 (mLMIR3)/CD300f is an inhibitory receptor containing 2 immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and a single immunoreceptor tyrosine-based switch motif (ITSM).We have recently demonstrated that extracellular ceramide is a ligand for mLMIR3/CD300f, which is a negative regulator of high-affinity IgE receptor (FcεRI)-mediated activation of mast cells. Although ceramide is a major ligand for mLMIR3, both sphingomyelin and ceramide act as physiological ligands for hLMIR3 in mast cells, thereby inhibiting FcεRI-mediated activation of mast cells. These results will help understand the intrinsic mechanism by which excessive activation of mast cells is prevented in human beings, leading to the development of novel therapeutic strategies against allergic diseases.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.2015
Author(s)
Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J
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Journal Title
Gut
Volume: 印刷中
Issue: 5
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FceRI-mediated mast cell activation.2014
Author(s)
Izawa, K., Isobe, M., Matsukawa, T., Ito, S., Maehara, A., Takahashi, M., Yamanishi, Y., Kaitani, A., Oki, T., Okumura, K., *Kitamura, T., and *Kitaura, J.
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Journal Title
J. Allergy. Clin. Immunol.
Volume: 133
Issue: 1
Pages: 270-273
DOI
Related Report
Peer Reviewed
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[Presentation] Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation.2013
Author(s)
Izawa Kumi, Isobe Masamichi, Matsukawa Toshihiro, Maehara Akie, Yamanishi Yoshinori, Takahashi Mariko, Kaitani Ayako, Okumura Ko, Kitamura Toshio, Kitaura Jiro
Organizer
日本免疫学会総会・学術集会
Place of Presentation
幕張メッセ
Related Report
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[Book] 炎症と免疫2014
Author(s)
北浦次郎、伊沢久未、北村俊雄
Total Pages
4
Publisher
先端医学社
Related Report
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[Book] 生化学2013
Author(s)
北浦次郎、伊沢久未、北村俊雄
Total Pages
5
Publisher
日本生化学会
Related Report
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