| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Repeated hepatectomy is widely accepted as one of the potentially curative treatments for primary and secondary liver neoplasms. But repeated hepatectomy has two major problems; postoperative adhesion and decreased regenerating ability of the remnant liver. We have already reported that the transplantation of mesothelial progenitor cells prevented postoperative adhesion and promoted liver regeneration in the mice practical partial hepatectomy model. In this study, we revealed the anti-adhesive effect of mesothelial cells transplantation in the miniature pig hepatectomy model. In addition, we showed that an allogeneic transplantation was as effective as a syngeneic transplantation in mice.
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