A rat model of posterior nasal neurectomy.

• Project/Area Number: 25893055
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: NISHIJIMA Hironobu 東京大学, 保健・健康推進本部, 助教 (50704938)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: アレルギー性鼻炎 / 後鼻神経切断術 / 鼻粘膜 / アレルギー / 鼻汁分泌 / 神経免疫 / 耳鼻咽喉科学

Outline of Final Research Achievements

We investigated the neural regulation of posterior nasal nerve on the nasal respiratory mucosa, especially in the pathophysiology of allergic rhinitis. We developed a rat model of posterior nasal neurectomy (PNN). We investigated the influence of impaired innervation on the nasal respiratory mucosa and the effect of PNN for the allergic rhinitis model rat.
PNN induced denervation in the nasal respiratory mucosa and reduced nasal secretion. In the allergic rhinitis model, PNN did not alleviate the nasal symptoms, such as sneezing and scratching, but reduced nasal secretion.
These findings suggest the posterior nasal nerve is not responsible primarily for regulation of allergic reactions.

Research Products

• [Journal Article] The effect of a first-generation H1-antihistamine on postural control: a preliminary study in healthy volunteers. (2013)
  • Author(s): Chihara Y, Sato A, Ohtani M, Fujimoto C, Hayashi T, Nishijima H, Yagi M, Iwasaki S.
  • Journal Title: Experimental Brain Research Volume: 231 Issue: 3 Pages: 257-266
  • DOI: 10.1007/s00221-013-3675-1
  • Peer Reviewed
• [Presentation] 後鼻神経切断術がアレルギー性鼻炎モデルラットの症状に及ぼす影響 (2015)
  • Author(s): 西嶌大宣、近藤健二、平野真希子、菊田周、上羽瑠美、籠谷領二、岩村均、安原一夫、山岨達也
  • Organizer: 第116回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2015-05-20 – 2015-05-23
• [Presentation] 後鼻神経切断術ラットモデルにおける鼻汁量の変化とアレルギー性鼻炎の病態に及ぼす影響の解析 (2014)
  • Author(s): 西嶌大宣、近藤健二、平野真希子、籠谷領二、菊田周、鈴川佳吾、山岨達也
  • Organizer: 第53回日本鼻科学会総会・学術講演会
  • Place of Presentation: コングレコンベンションセンター（大阪）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] ラット後鼻神経切断モデルにおける鼻粘膜の組織学的変化
  • Author(s): 西嶌大宣、近藤健二、山岨達也
  • Organizer: 日本鼻科学会総会・学術講演会
  • Place of Presentation: 福井フェニックスプラザ（福井）
• [Presentation] Histological changes of nasal mucosa in a rat model of vidian neurectomy
  • Author(s): Hironobu Nishijima, Kenji Kondo, Tatsuya Yamasoba
  • Organizer: Taiwan-Japan conference on otolaryngology head and neck surgery
  • Place of Presentation: International convention center (Taipei)