| Project/Area Number |
25893073
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
USUMI Risa 東京医科歯科大学, 歯学部附属病院, 医員 (90706946)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯科矯正学 / 咬合刺激低下 / LIPUS / 歯根膜細胞 / VEGF |
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| Outline of Final Research Achievements |
In orthodontic clinical, root resorption,bone adhesions and pulp necrosis caused When we make sudden orthodontic force to occlusal hypofunctional teeth. We revealed the influence of the vascular system under the orthodontic hypofunctional tooth movement, and we have recommended the ischemic injury in the periodontal ligament.It is not revealed its detailed mechanism, but in this study, In acidosis during ischemic injury, it has been suggested that proton sensor GPR4 are involved in bone destruction of cAMP as a second messenger. Also, LIPUS to tissue repair in ischemic injury of periodontal ligament tissue has been suggested to be useful.
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