The effect of high glucose and high insulin state on beta-amyloid production

• Project/Area Number: 25893077
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Niigata University
• Principal Investigator: TOKUTAKE Takayoshi 新潟大学, 医歯学総合病院, 医員 (00707838)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: アルツハイマー型認知症 / インスリン / グルコース / アミロイドβ / アルツハイマー病

Outline of Final Research Achievements

Numerous epidemiological studies have shown that patients with diabetes mellitus (DM) have increased risk of developing Alzheimer disease(AD). We conducted a reserch to verify high glucose condition in AD pathogenesis and here provide following findings. i) high glucose condition faciletates β-amyoid(Aβ) production in cultured neuronal cells. ⅱ）high insulin state facilitates
Aβ production.
These findings suggest that hyperglycemia and hyperinsulinemia occurring in patients with DM may accelerate AD pathogenesis by facilitating Aβ production in neurons.

Research Products

• [Journal Article] Systematic review and meta-analysis of Japanese familial Alzheimer's disease and FTDP-17. (2015)
  • Author(s): Ｋａｓｕｇａ，ｅｔ ａｌ
  • Journal Title: Ｊｏｕｒｎａｌ ｏｆ Ｈｕｍａｎ Ｇｅｎｅｔｉｃｓ Volume: in press Issue: 5 Pages: 1-3
  • DOI: 10.1038/jhg.2015.15
  • Peer Reviewed / Open Access
• [Journal Article] ApoE-isoform-dependent cellular uptake of amyloid-β is mediated by lipoprotein receptor LR11/SorLA. (2015)
  • Author(s): Ｙａｊｉｍａ，ｅｔ ａｌ
  • Journal Title: Biochemical and Biophysical Research Communications Volume: ４５６ Issue: 1 Pages: 482-488
  • DOI: 10.1016/j.bbrc.2014.11.111
  • Peer Reviewed
• [Journal Article] Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation. (2014)
  • Author(s): Tokutake T, Ishikawa A, Yoshimura N, Miyashita A, Kuwano R, Nishizawa M, Ikeuchi T
  • Journal Title: Parkinsonism Relat Disord Volume: 20 Issue: 2 Pages: 262-264
  • DOI: 10.1016/j.parkreldis.2013.11.008
  • Peer Reviewed
• [Journal Article] Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation (2014)
  • Author(s): Tokutake et al.
  • Journal Title: Parkinsonism & Related Disorders Volume: 20 Pages: 262-264
  • Peer Reviewed
• [Presentation] SNCA p.G51D変異を同定した若年発症パーキンソン病患者の分子臨床遺伝学的解析 (2014)
  • Author(s): 徳武孝允 他
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市 福岡国際会議場
  • Year and Date: 2014-05-22
• [Presentation] 脳アミロイドアンギオパチー関連炎症の画像，臨床症状，バイオマーカーの検討 (2013)
  • Author(s): 徳武孝允 他
  • Organizer: 第32回認知症学会学術集会
  • Place of Presentation: 松本・キッセイ文化ホール