| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Periodontitis as periodontal bacterial infection has been implicated as a risk factor for diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. TRP channels are Ca2+ permeable cation channels, which play an important role in the pathogenesis and progression of inflammatory responses and metabolic disorders. The present study has demonstrated that TRPV1 can regulate inflammatory responses and lipid metabolism in the liver. This result suggests that TRP channel may affect the pathological mechanism of systemic diseases caused by periodontitis.
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