Impact of gut microbiota on promotion of liver carcinogenesis

• Project/Area Number: 25893081
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kanazawa University
• Principal Investigator: IIDA Noriho 金沢大学, 医学系, 助教 (40705604)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肝癌 / 腸内細菌 / 肝発癌

Outline of Final Research Achievements

Sequencing with fecal DNA harvested from hepatocellular carcinoma (HCC) patients, chronic liver disease (CLD) patients and healthy donors (HD) reveals that the microbiota of the HCC patients was differently clustered from HD microbiota. Liver carcinogenesis was observed in 67 % of mice transplanted with feces of HCC patients, but no carcinogenesis was seen in the mice transplanted with HD feces.