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Understanding the effect of lactate metabolism on cancer-mediated immunoregulation in head and neck cancer

Research Project

Project/Area Number 25893085
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionGifu University

Principal Investigator

OHASHI Toshimitsu  岐阜大学, 医学部附属病院, 助教 (80707860)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords腫瘍免疫 / がん代謝 / 頭頸部癌 / 乳酸 / データ整理 / 検体収集 / PET-CT
Outline of Final Research Achievements

Understanding the effect of lactate metabolism on cancer-mediated immunoregulation in head and neck cancer, I analyzed gene expression in cancer by quantitative RT-PCR. Glucose transporters-1 (GLUT-1) and Lactate dehydrogenase-A (LDH-A), which are linked with enhanced glycolysis, have relevance for intratumor lactate concentration. Meanwhile, CD68 and CSF-1, which are known as M2 macrophage marker, have also relevance for intratumor lactate concentration. Furthermore, GLUT-1 and LDH-A have relevance for CD163 which is also known as M2 marker.
These results are suggest that the factors associated with enhanced glycolysis have somethings to do with M2 macrophage polarization. For cancer patients, the therapy targeting enhanced glycolysis is one potential strategy that improves the immunosuppressive status.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (3 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Development of a dendritic cell-targeting lipopeptide as an immunoadjuvant that inhibits tumor growth without inducing local inflammation.2014

    • Author(s)
      Akazawa T, Ohashi T, Nakajima H, Nishizawa Y, Kodama K, Sugiura K, Inaba T, Inoue N
    • Journal Title

      International Journal of Cancer

      Volume: 135(12) Pages: 2847-2856

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 頭頸部癌におけるFDG-PETと炎症マーカーとの関連性の検討2014

    • Author(s)
      大橋敏充、久世文也、青木光広、水田啓介、伊藤八次
    • Organizer
      第38回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 頭頸部癌におけるFDG-PETと炎症マーカーとの関連性の検討2014

    • Author(s)
      大橋 敏充
    • Organizer
      第38回日本頭頸部癌学会
    • Place of Presentation
      ビッグサイトTFTホール
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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